Is semantic verbal fluency impairment explained by executive function deficits in schizophrenia?

Is semantic verbal fluency impairment explained by executive function deficits in schizophrenia?

Author Berberian, Arthur de Almeida Autor UNIFESP Google Scholar
Moraes, Giovanna V. Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Fonseca, Ana O. Autor UNIFESP Google Scholar
Scarpato, Bruno Sini Autor UNIFESP Google Scholar
Vicente, Marcella de Oliveira Autor UNIFESP Google Scholar
Seabra, Alessandra G. Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Lacerda, Acioly Luiz Tavares de Autor UNIFESP Google Scholar
Abstract Objective: To investigate if verbal fluency impairment in schizophrenia reflects executive function deficits or results from degraded semantic store or inefficient search and retrieval strategies. Method: Two groups were compared: 141 individuals with schizophrenia and 119 healthy age and education-matched controls. Both groups performed semantic and phonetic verbal fluency tasks. Performance was evaluated using three scores, based on 1) number of words generated

2) number of clustered/ related words

and 3) switching score. A fourth performance score based on the number of clusters was also measured. Results: Individuals with schizophrenia produced fewer words than controls. After controlling for the total number of words produced, a difference was observed between the groups in the number of cluster-related words generated in the semantic task. In both groups, the number of words generated in the semantic task was higher than that generated in the phonemic task, although a significant group vs. fluency type interaction showed that subjects with schizophrenia had disproportionate semantic fluency impairment. Working memory was positively associated with increased production of words within clusters and inversely correlated with switching. Conclusion: Semantic fluency impairment may be attributed to an inability (resulting from reduced cognitive control) to distinguish target signal from competing noise and to maintain cues for production of memory probes.
Keywords Psychosis
schizophrenia
cognitive neuroscience
chronic psychiatric illness
language
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Sponsor Fundacao de Amparo e Pesquisa do Estado de Sao Paulo (FAPESP)
Grant number FAPESP: 2011/50740-5
FAPESP: 2007/58630-9
Date 2016
Published in Revista Brasileira De Psiquiatria. Sao Paulo, v. 38, n. 2, p. 121-126, 2016.
ISSN 1516-4446 (Sherpa/Romeo, impact factor)
Publisher Assoc Brasileira Psiquiatria
Extent 121-126
Origin http://dx.doi.org/10.1590/1516-4446-2015-1663
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000378234800005
SciELO ID S1516-44462016000200121 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/56088

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