Increased vascular sympathetic modulation in mice with Mas receptor deficiency

Increased vascular sympathetic modulation in mice with Mas receptor deficiency

Author Casali, Karina Rabello Autor UNIFESP Google Scholar
Dartora, Daniela Ravizzoni Google Scholar
Moura, Marina Google Scholar
Bertagnolli, Mariane Google Scholar
Bader, Michael Autor UNIFESP Google Scholar
Haibara, Andrea Google Scholar
Alenina, Natalia Google Scholar
Irigoyen, Maria Claudia Autor UNIFESP Google Scholar
Santos, Robson A. Google Scholar
Abstract Introduction: The angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas axis could modulate the heart rate (HR) and blood pressure variabilities (BPV) which are important predictors of cardiovascular risk and provide information about the autonomic modulation of the cardiovascular system. Therefore we investigated the effect of Mas deficiency on autonomic modulation in wild type and Mas-knockout (KO) mice. Methods: Blood pressure was recorded at high sample rate (4000 Hz). Stationary sequences of 200-250 beats were randomly chosen. Frequency domain analysis of HR and BPV was performed with an autoregressive algorithm on the pulse interval sequences and on respective systolic sequences. Results: The KO group presented an increase of systolic arterial pressure (SAP

127.26 +/- 11.20 vs 135.07 +/- 6.98 mmHg), BPV (3.54 +/- 1.54 vs 5.87 +/- 2.12 mmHg(2)), and low-frequency component of systolic BPV (0.12 +/- 0.11 vs 0.47 +/- 0.34 mmHg(2)). Conclusions: The deletion of Mas receptor is associated with an increase of SAP and with an increased BPV, indicating alterations in autonomic control. Increase of sympathetic vascular modulation in absence of Mas evidences the important role of Ang-(1-7)/Mas on cardiovascular regulation. Moreover, the absence of significant changes in HR and HRV can indicate an adaptation of autonomic cardiac balance. Our results suggest that the Ang-(1-7)/Mas axis seems more important in autonomic modulation of arterial pressure than HR.
Keywords Renin-angiotensin system
Mas receptor
autonomic modulation
blood pressure variability
heart rate variability
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor National Institute of Science and Technology in Nanobiopharmaceutics
National Counsel of Technological and Scientific Development (Cnpq)
Programa Nacional de Pos Doutorado (PNPD-CAPES)
Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
Date 2016
Published in Journal Of The Renin-Angiotensin-Aldosterone System. London, v. 17, n. 2, p. -, 2016.
ISSN 1470-3203 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent -
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000378273800001

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