Differential Sympathetic Vasomotor Activation Induced by Liver Cirrhosis in Rats

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dc.contributor.author Estrela, Heder Frank Gianotto [UNIFESP]
dc.contributor.author Damasio, Elaine S. [UNIFESP]
dc.contributor.author Fonseca, Eduardo K. U. N. [UNIFESP]
dc.contributor.author Bergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.author Campos, Ruy Ribeiro [UNIFESP]
dc.date.accessioned 2020-07-22T13:23:08Z
dc.date.available 2020-07-22T13:23:08Z
dc.date.issued 2016
dc.identifier http://dx.doi.org/10.1371/journal.pone.0152512
dc.identifier.citation Plos One. San Francisco, v. 11, n. 4, p. -, 2016.
dc.identifier.issn 1932-6203
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/56056
dc.description.abstract We tested the hypothesis that there is a topographical sympathetic activation in rats submitted to experimental cirrhosis. Baseline renal (rSNA) and splanchnic (sSNA) sympathetic nerve activities were evaluated in anesthetized rats. In addition, we evaluated main arterial pressure (MAP), heart rate (HR), and baroreceptor reflex sensitivity (BRS). Cirrhotic Wistar rats were obtained by bile duct ligation (BDL). MAP and HR were measured in conscious rats, and cardiac BRS was assessed by changes in blood pressure induced by increasing doses of phenylephrine or sodium nitroprusside. The BRS and baseline for the control of sSNA and rSNA were also evaluated in urethane-anesthetized rats. Cirrhotic rats had increased baseline sSNA (BDL, 102 vs control, 58 spikes/s en
dc.description.abstract p<0.05), but no baseline changes in the rSNA compared to controls. These data were accompanied by increased splanchnic BRS (p<0.05) and decreased cardiac (p<0.05) and renal BRS (p<0.05). Furthermore, BDL rats had reduced basal MAP (BDL, 93 vs control, 101 mmHg en
dc.description.abstract p<0.05) accompanied by increased HR (BDL, 378 vs control, 356 en
dc.description.abstract p<0.05). Our data have shown topographical sympathetic activation in rats submitted to experimental cirrhosis. The BDL group had increased baseline sSNA, independent of dysfunction in the BRS and no changes in baseline rSNA. However, an impairment of rSNA and HR control by arterial baroreceptor was noted. We suggest that arterial baroreceptor impairment of rSNA and HR is an early marker of cardiovascular dysfunction related to liver cirrhosis and probably a major mechanism leading to sympathoexcitation in decompensated phase. en
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorship Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.format.extent -
dc.language.iso eng
dc.publisher Public Library Science
dc.relation.ispartof Plos One
dc.rights Acesso aberto
dc.title Differential Sympathetic Vasomotor Activation Induced by Liver Cirrhosis in Rats en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2013/22522-9
dc.description.sponsorshipID CNPq: 472613/2013-8
dc.description.sponsorshipID CNPq: 301840/2013-0
dc.identifier.file WOS000373608000023.pdf
dc.identifier.doi 10.1371/journal.pone.0152512
dc.description.source Web of Science
dc.identifier.wos WOS:000373608000023
dc.coverage San Francisco
dc.citation.volume 11
dc.citation.issue 4



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