An Overview of B-1 Cells as Antigen-Presenting Cells

An Overview of B-1 Cells as Antigen-Presenting Cells

Author Popi, Ana Flavia Autor UNIFESP Google Scholar
Longo-Maugéri, Ieda Maria Autor UNIFESP Google Scholar
Mariano, Mario Autor UNIFESP Google Scholar
Abstract The role of B cells as antigen-presenting cells (APCs) has been extensively studied, mainly in relation to the activation of memory T cells. Considering the B cell subtypes, the role of B-1 cells as APCs is beginning to be explored. Initially, it was described that B-1 cells are activated preferentially by T-independent antigens. However, some reports demonstrated that these cells are also involved in a T-dependent response. The aim of this review is to summarize information about the ability of B-1 cells to play a role as APCs and to briefly discuss the role of the BCR and toll-like receptor signals in this process. Furthermore, some characteristics of B-1 cells, such as natural IgM production and phagocytic ability, could interfere in the participation of these cells in the onset of an adaptive response.
Keywords B-1 cells
APCs
BCR
TLR
autoimmune diseases
xmlui.dri2xhtml.METS-1.0.item-coverage Lausanne
Language English
Sponsor FAPESP
Grant number FAPESP: 2008/58561-0
FAPESP: 2015/01986-2
Date 2016
Published in Frontiers In Immunology. Lausanne, v. 7, p. -, 2016.
ISSN 1664-3224 (Sherpa/Romeo, impact factor)
Publisher Frontiers Media Sa
Extent -
Origin http://dx.doi.org/10.3389/fimmu.2016.00138
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000373665300001
URI https://repositorio.unifesp.br/handle/11600/56054

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