The Association of Serum 25-Hydroxyvitamin D With Biomarkers of Hemolysis in Pediatric Patients With Sickle Cell Disease

The Association of Serum 25-Hydroxyvitamin D With Biomarkers of Hemolysis in Pediatric Patients With Sickle Cell Disease

Author Adegoke, Samuel Ademola Autor UNIFESP Google Scholar
Braga, Josefina Aparecida Pellegrini Autor UNIFESP Google Scholar
Adekile, Adekunle D. Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Abstract Although vitamin D deficiency (VDD) has been linked to anemia among sickle cell disease (SCD), its relationship with hemolysis is unclear. Serum 25-hydroxyvitamin D and biomarkers of hemolysis (hemoglobin [Hb]/hematocrit, reticulocyte percentage, absolute reticulocyte, and lactate dehydrogenase [LDH] levels) in 36 hydroxyurea-naive SCD children were quantified. Correlations were significantly positive with Hb/hematocrit (r=0.40, P=0.017

r=0.45, P=0.006, respectively)

inverse with reticulocyte percentage, absolute reticulocyte, and LDH (r=-0.44, P=0.008

r=-0.47, P=0.007

r=-0.45, P=0.007, respectively). In VDD groups, Hb was lower (P=0.014), reticulocyte counts and LDH were higher (P=0.047 and 0.003, respectively). Serum 25-hydroxyvitamin D correlated with biomarkers of hemolysis in SCD and VDD may play a role in SCD pathogenesis.
Keywords biomarkers
hemolysis
pediatric sickle cell disease
25-hydroxyvitamin D
xmlui.dri2xhtml.METS-1.0.item-coverage Philadelphia
Language English
Sponsor CAPES/SUS (Coordination of Improvement of Higher Level Personnel)
Brazil National Council for Research (CNPq)
Date 2018
Published in Journal Of Pediatric Hematology Oncology. Philadelphia, v. 40, n. 2, p. 159-162, 2018.
ISSN 1077-4114 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 159-162
Origin http://dx.doi.org/10.1097/MPH.0000000000000783
Access rights Closed access
Type Article
Web of Science ID WOS:000428181500033
URI https://repositorio.unifesp.br/handle/11600/55892

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