TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017)

TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria (vol 7, 2017)

Author Barboza, Renato Autor UNIFESP Google Scholar
Lima, Flavia Afonso Google Scholar
Reis, Aramys Silva Google Scholar
Murillo, Oscar Javier Google Scholar
Peixoto, Erika Paula Machado Google Scholar
Bandeira, Carla Leticia Google Scholar
Fotoran, Wesley Luzetti Google Scholar
Sardinha, Luis Roberto Google Scholar
Wunderlich, Gerhard Google Scholar
Bevilacqua, Estela Google Scholar
D'Imperio Lima, Maria Regina Google Scholar
Alvarez, Jose Maria Google Scholar
Maranhao Costa, Fabio Trindade Google Scholar
Goncalves, Ligia Antunes Google Scholar
Epiphanio, Sabrina Google Scholar
Marinho, Claudio Romero Farias Google Scholar
Abstract Malaria-associate pregnancy has a signifcant impact on infant morbidity and mortality. The detrimental efects of malaria infection during pregnancy have been shown to correlate with immune activation in the placental tissue. Herein we sought to evaluate the efect of Toll-like receptors (TLRs) activation on placental malaria (PM) development by using the Plasmodium berghei NK65GFP infection model. We observed that activation of the innate immune system by parasites leads to PM due to local infammation. We identifed TLR4 activation as the main pathway involved in the infammatory process in the placental tissue since the absence of functional TLR4 in mice leads to a decrease in the pro-infammatory responses, which resulted in an improved pregnancy outcome. Additionally, a similar result was obtained when infected pregnant mice were treated with IAXO-101, a TLR4/CD14 blocker. Together, this study illustrates the importance of TLR4 signalling for the generation of the severe infammatory response involved in PM pathogenesis. Therefore, our results implicate that TLR4 blockage could be a potential candidate for therapeutic interventions to reduce malaria-induced pathology both in the mother and the fetus.
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Date 2018
Published in Scientific Reports. London, v. 8, 2018.
ISSN 2045-2322 (Sherpa/Romeo, impact factor)
Publisher Nature Publishing Group
Extent -
Access rights Open access Open Access
Type Errata
Web of Science ID WOS:000426652400004

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