Association of a neuronal nitric oxide synthase gene polymorphism with levodopa-induced dyskinesia in Parkinson's disease

Association of a neuronal nitric oxide synthase gene polymorphism with levodopa-induced dyskinesia in Parkinson's disease

Author Santos-Lobato, Bruno Lopes Google Scholar
Borges, Vanderci Autor UNIFESP Google Scholar
Ferraz, Henrique Ballalai Autor UNIFESP Google Scholar
Mata, Ignacio Fernandez Google Scholar
Zabetian, Cyrus P. Google Scholar
Tumas, Vitor Google Scholar
Abstract Background: Levodopa-induced dyskinesia (LID) is a common complication of advanced Parkinson's disease (PD). PD physiopathology is associated with dopaminergic and non-dopaminergic pathways, including the nitric oxide system. The present study aims to examine the association of a neuronal nitric oxide synthase gene (NOS1) single nucleotide polymorphism (rs2682826) with LID in PD patients. Methods and results: We studied 186 PD patients using levodopa. The presence of LID was defined as a MDS-UPDRS Part IV score >= 1 on item 4.1. We tested for association between NOS1 rs2682826 and the presence, daily frequency, and functional impact of LID using regression models, adjusting for important covariates. There was no significant association between genotype and any of the LID-related variables examined. Conclusions: Our results suggest that this NOS1 polymorphism does not contribute to LID susceptibility or severity. However, additional studies that include a comprehensive set of NOS1 variants will be needed to fully define the role of this gene in LID. (C) 2017 Elsevier Inc. All rights reserved.
Keywords Dyskinesia
Parkinson's disease
Levodopa
Nitric oxide
NOS1 gene
xmlui.dri2xhtml.METS-1.0.item-coverage San Diego
Language English
Sponsor Parkinson's Disease Foundation
International Parkinson and Movement Disorder Society
Date 2018
Published in Nitric Oxide-Biology And Chemistry. San Diego, v. 74, p. 86-90, 2018.
ISSN 1089-8603 (Sherpa/Romeo, impact factor)
Publisher Academic Press Inc Elsevier Science
Extent 86-90
Origin http://dx.doi.org/10.1016/j.niox.2017.06.004
Access rights Closed access
Type Article
Web of Science ID WOS:000426538300011
URI https://repositorio.unifesp.br/handle/11600/55795

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