ATZ (3-amino-1,2,4-triazole) injected into the fourth cerebral ventricle influences the Bezold-Jarisch reflex in conscious rats

ATZ (3-amino-1,2,4-triazole) injected into the fourth cerebral ventricle influences the Bezold-Jarisch reflex in conscious rats

Autor Valenti, Vitor Engrácia Autor UNIFESP Google Scholar
Abreu, Luiz Carlos de Google Scholar
Sato, Monica A. Google Scholar
Ferreira, Celso Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Faculdade de Medicina do ABC Departamento de Morfologia e Fisiologia
Resumo OBJECTIVES: Many studies have investigated the importance of oxidative stress on the cardiovascular system. In this study we evaluated the effects of central catalase inhibition on cardiopulmonary reflex in conscious Wistar rats. METHODS: Male Wistar rats were implanted with a stainless steel guide cannula in the fourth cerebral ventricle. The femoral artery and vein were cannulated for mean arterial pressure and heart rate measurement and for drug infusion, respectively. After basal mean arterial pressure and heart rate recordings, the cardiopulmonary reflex was tested with a dose of phenylbiguanide (PBG, 8 μg/kg, bolus). Cardiopulmonary reflex was evaluated before and μl15 minutes after 1.0 μl 3-amino-1,2,4-triazole (ATZ, 0.01g/100μl)0.01 g/100 μl) injection into the fourth cerebral ventricle. Vehicle treatment did not change cardiopulmonary reflex responses. RESULTS: Central ATZ significantly increased hypotensive responses without influencing the bradycardic reflex. CONCLUSION: ATZ injected into the fourth cerebral ventricle increases sympathetic inhibition but does not change the parasympathetic component of the cardiopulmonary reflex in conscious Wistar rats.
Palavra-chave Reflex
Oxidative Stress
Catalase
Medulla Oblongata
Cardiovascular System
Idioma Inglês
Data de publicação 2010-01-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 65, n. 12, p. 1339-1343, 2010.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
Publicador Faculdade de Medicina / USP
Extensão 1339-1343
Fonte http://dx.doi.org/10.1590/S1807-59322010001200018
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000288493400018
SciELO S1807-59322010001200018 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/5576

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