Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis

Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis

Author Gimenez, Andrea Autor UNIFESP Google Scholar
Storrer, Karin Mueller Autor UNIFESP Google Scholar
Kuranishi, Lilian Tiemi Autor UNIFESP Google Scholar
Soares, Maria Raquel Autor UNIFESP Google Scholar
Ferreira, Rimarcs Gomes Autor UNIFESP Google Scholar
Pereira, Carlos Alberto de Castro Autor UNIFESP Google Scholar
Abstract The predictive value of the decline in FVC by >= 10% on survival in patients with fibrotic hypersensitivity pneumonitis is unknown. Of 112 patients included, 66 (59%) had surgical lung biopsies. Patients with >= 10% decline in predicted FVC after 6-12 months had a significantly increased risk of all-cause mortality (median survival 53 months, 95% CI 37 to 69 vs 139 months, 95% CI 66 to 212 months, p= 0.007). On multivariate analysis remained associated with increasing mortality: decline in FVC by >= 10% (HR 4.13, 95% CI 1.96 to 8.70, p=0.005), lower FVC% (HR 1.03, 95% CI 1.01 to 1.05, p=0.003) and with decreasing mortality improvement with antigen avoidance (HR 0.18, 95% CI 0.04 to 0.77, p=0.021).
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Date 2018
Published in Thorax. London, v. 73, n. 4, p. 391-392, 2018.
ISSN 0040-6376 (Sherpa/Romeo, impact factor)
Publisher Bmj Publishing Group
Extent 391-392
Access rights Closed access
Type Article
Web of Science ID WOS:000428933000019

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