The effect of nutritional intervention on the lipid profile and dietary intake of adolescents with juvenile systemic lupus erythematosus: a randomized, controlled trial

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dc.contributor.author Silva, S. G. L. da [UNIFESP]
dc.contributor.author Terreri, Maria Teresa Ramos Ascensão [UNIFESP]
dc.contributor.author Abad, Thais Tobaruela Ortiz [UNIFESP]
dc.contributor.author Machado, D. [UNIFESP]
dc.contributor.author Fonseca, Fernando Luiz Affonso [UNIFESP]
dc.contributor.author Hix, S.
dc.contributor.author Suano de Souza, Fabiola Isabel [UNIFESP]
dc.contributor.author Sarni, Roseli Oselka Saccardo [UNIFESP]
dc.contributor.author Len, Claudio Arnaldo [UNIFESP]
dc.date.accessioned 2020-07-20T16:31:07Z
dc.date.available 2020-07-20T16:31:07Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.1177/0961203317751851
dc.identifier.citation Lupus. London, v. 27, n. 5, p. 820-827, 2018.
dc.identifier.issn 0961-2033
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/55717
dc.description.abstract Objective This study sought to evaluate the effects of a nutritional intervention on the lipid metabolism biomarkers associated with cardiovascular risk, and their variation over time, in juvenile systemic lupus erythematosus (JSLE) patients. This study also investigated the relationships between these biomarkers and dietary intake, nutritional status, disease variables, and medication used. Methods A total of 31 10- to 19-year-old female adolescents with JSLE for at least six months were analyzed. The participants were randomly allocated to two groups: nutritional intervention or control. The intervention group received verbal and printed nutritional instructions once per month over nine months. Before and after the intervention, the participants underwent assessments of anthropometry en
dc.description.abstract dietary intake en
dc.description.abstract physical activity en
dc.description.abstract socioeconomic status en
dc.description.abstract total cholesterol and fractions en
dc.description.abstract triglycerides en
dc.description.abstract apolipoprotein A (Apo A-I) en
dc.description.abstract apolipoprotein B (Apo B) en
dc.description.abstract paraoxonase (PON) activity (a) and amount (q) en
dc.description.abstract myeloperoxidase (MPO) en
dc.description.abstract and small, dense LDL-c (sdLDL) particles. Results After nine months, we found significant reductions in the calorie, carbohydrate, total fat, saturated fat, and trans fat intakes in the intervention compared with the control group over time. The PONa/HDL-c ratio increased by 3.18 U/ml/mg/dl in the intervention group and by 0.63 U/ml/mg/dl in the control group (p=0.037). Unlike the intervention group, the sdLDL levels of the control group worsened over time (p=0.018). Conclusion The present study detected a reduction in calorie and fat intake, which indicates an improvement of HDL-c function and possible protection against cardiovascular risk for the intervention group. en
dc.description.sponsorship Sao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP)
dc.description.sponsorship Brazilian Federal Agency for Support and Evaluation of Graduate Education (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.format.extent 820-827
dc.language.iso eng
dc.publisher Sage Publications Ltd
dc.relation.ispartof Lupus
dc.rights Acesso restrito
dc.subject Systemic lupus erythematosus en
dc.subject adolescent en
dc.subject dyslipidemia en
dc.subject apolipoprotein A-I en
dc.subject nutritional education en
dc.subject paraoxonase en
dc.title The effect of nutritional intervention on the lipid profile and dietary intake of adolescents with juvenile systemic lupus erythematosus: a randomized, controlled trial en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Pediat, Rua Borges Lagoa 802, BR-04038001 Sao Paulo, SP, Brazil
dc.description.affiliation Sch Med ABC, Lab Clin Anal, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Sao Paulo, SP, Brazil
dc.description.affiliation Fac Med ABC, Sch Med ABC, Dept Morphol & Physiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Pediat, Rua Borges Lagoa 802, BR-04038001 Sao Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 2012/08529-8
dc.description.sponsorshipID CNPq: 303752/2015-7
dc.identifier.doi 10.1177/0961203317751851
dc.description.source Web of Science
dc.identifier.wos WOS:000429894300016
dc.coverage London
dc.citation.volume v. 27
dc.citation.issue 5



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