The effect of nutritional intervention on the lipid profile and dietary intake of adolescents with juvenile systemic lupus erythematosus: a randomized, controlled trial

The effect of nutritional intervention on the lipid profile and dietary intake of adolescents with juvenile systemic lupus erythematosus: a randomized, controlled trial

Author Silva, S. G. L. da Autor UNIFESP Google Scholar
Terreri, Maria Teresa Ramos Ascensão Autor UNIFESP Google Scholar
Abad, Thais Tobaruela Ortiz Autor UNIFESP Google Scholar
Machado, D. Autor UNIFESP Google Scholar
Fonseca, Fernando Luiz Affonso Autor UNIFESP Google Scholar
Hix, S. Google Scholar
Suano de Souza, Fabiola Isabel Autor UNIFESP Google Scholar
Sarni, Roseli Oselka Saccardo Autor UNIFESP Google Scholar
Len, Claudio Arnaldo Autor UNIFESP Google Scholar
Abstract Objective This study sought to evaluate the effects of a nutritional intervention on the lipid metabolism biomarkers associated with cardiovascular risk, and their variation over time, in juvenile systemic lupus erythematosus (JSLE) patients. This study also investigated the relationships between these biomarkers and dietary intake, nutritional status, disease variables, and medication used. Methods A total of 31 10- to 19-year-old female adolescents with JSLE for at least six months were analyzed. The participants were randomly allocated to two groups: nutritional intervention or control. The intervention group received verbal and printed nutritional instructions once per month over nine months. Before and after the intervention, the participants underwent assessments of anthropometry

dietary intake

physical activity

socioeconomic status

total cholesterol and fractions

triglycerides

apolipoprotein A (Apo A-I)

apolipoprotein B (Apo B)

paraoxonase (PON) activity (a) and amount (q)

myeloperoxidase (MPO)

and small, dense LDL-c (sdLDL) particles. Results After nine months, we found significant reductions in the calorie, carbohydrate, total fat, saturated fat, and trans fat intakes in the intervention compared with the control group over time. The PONa/HDL-c ratio increased by 3.18 U/ml/mg/dl in the intervention group and by 0.63 U/ml/mg/dl in the control group (p=0.037). Unlike the intervention group, the sdLDL levels of the control group worsened over time (p=0.018). Conclusion The present study detected a reduction in calorie and fat intake, which indicates an improvement of HDL-c function and possible protection against cardiovascular risk for the intervention group.
Keywords Systemic lupus erythematosus
adolescent
dyslipidemia
apolipoprotein A-I
nutritional education
paraoxonase
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor Sao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP)
Brazilian Federal Agency for Support and Evaluation of Graduate Education (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Grant number FAPESP: 2012/08529-8
CNPq: 303752/2015-7
Date 2018
Published in Lupus. London, v. 27, n. 5, p. 820-827, 2018.
ISSN 0961-2033 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 820-827
Origin http://dx.doi.org/10.1177/0961203317751851
Access rights Closed access
Type Article
Web of Science ID WOS:000429894300016
URI https://repositorio.unifesp.br/handle/11600/55717

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