Effects of Aging in the Striatum and Substantia Nigra of a Parkinson's Disease Animal Model

Effects of Aging in the Striatum and Substantia Nigra of a Parkinson's Disease Animal Model

Author Ureshino, Rodrigo Portes Autor UNIFESP Google Scholar
Costa, Angelica Jardim Autor UNIFESP Google Scholar
Erustes, Adolfo Garcia Autor UNIFESP Google Scholar
Pereira, Gustavo Jose da Silva Autor UNIFESP Google Scholar
Sinigaglia-Coimbra, Rita Autor UNIFESP Google Scholar
Smaili, Soraya Soubhi Autor UNIFESP Google Scholar
Abstract Aging is a multifactorial process associated with functional deficits, and the brain is more prone to developing chronic degenerative diseases such as Parkinson's disease. Several groups have tried to correlate the age-related ultrastructural alterations to the neurodegeneration process using in vivo pharmacological models, but due to the limitations of the animal models, particularly in aged animals, the results are difficult to interpret. In this work, we investigated neurodegeneration induced by rotenone, as a pharmacological model of Parkinson's disease, in both young and aged Wistar rats. We assessed animal mobility, tyrosine hydroxylase staining in the substantia nigra pars compacta (SNpc), and TdT-mediated dUTP-biotin nick end labeling-positive nuclei and reactive oxygen species production in the striatum. Interestingly, the mobility impairment, dopaminergic neuron loss, and elevated number of apoptotic nuclei in the striatum of aged control rats were similar to young rotenone-treated animals. Moreover, we observed many ultrastructural alterations, such as swollen mitochondria in the striatum, and massive lipofuscin deposits in the SNpc of the aged rotenone-treated animals. We conclude that the rotenone model can be employed to explore age-related alterations in the ontogeny that can increase vulnerability in the striatum and SNpc, which may contribute to Parkinson's disease pathogenesis.
Keywords aging
Parkinson's disease model
rotenone
nigrostriatal pathway
mitochondria
lipofuscin
xmlui.dri2xhtml.METS-1.0.item-coverage Thousand Oaks
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP]
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq]
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Grant number FAPESP: 2012/08273-3
FAPESP: 2013/20073-2
Date 2018
Published in Toxicologic Pathology. Thousand Oaks, v. 46, n. 3, p. 348-358, 2018.
ISSN 0192-6233 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Inc
Extent 348-358
Origin http://dx.doi.org/10.1177/0192623318767065
Access rights Closed access
Type Article
Web of Science ID WOS:000432138800011
URI https://repositorio.unifesp.br/handle/11600/55668

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