Sleep deprivation precipitates the development of amphetamine-induced conditioned place preference in rats

Sleep deprivation precipitates the development of amphetamine-induced conditioned place preference in rats

Author Berro, Laís Fernanda Autor UNIFESP Google Scholar
Tufik, Sergio Brasil Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Abstract Sleep deprivation (SD) and amphetamine use are commonly associated conditions. SD shares similar neurobiological effects with psychostimulants, playing an important role in drug addiction, especially through conditioning manipulations. The aim of the present study was to investigate the effects of SD on the development of amphetamine-induced conditioned place preference (CPP) in a protocol with a reduced number of conditioning sessions. Male adult Wistar rats were submitted to 4 conditioning sessions (2 sessions/day) in the CPP apparatus, half with saline (non-drug-paired compartment) and half with 2 mg/kg amphetamine (drug-paired compartment) after control (home-cage maintained) or SD (6 h gentle handling method) conditions. Control animals did not express a preference for the amphetamine-paired compartment, showing that 2 conditioning sessions with the drug were not sufficient to establish CPP. On the other hand, animals submitted to SD during the conditioning sessions expressed a preference for the amphetamine-paired compartment, which was maintained across the entire test session. SD precipitated the development of CPP to amphetamine, showing that lack of sleep can contribute to the establishment of a conditioning between the drug effect and environmental cues.
Keywords Conditioned place preference
Amphetamine
Sleep
Sleep deprivation
Rats
xmlui.dri2xhtml.METS-1.0.item-coverage Clare
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Associacao Fundo de Incentivo a Pesquisa (AFIP)
Date 2018
Published in Neuroscience Letters. Clare, v. 671, p. 29-32, 2018.
ISSN 0304-3940 (Sherpa/Romeo, impact factor)
Publisher Elsevier Ireland Ltd
Extent 29-32
Origin http://dx.doi.org/10.1016/j.neulet.2018.02.010
Access rights Closed access
Type Article
Web of Science ID WOS:000430523700006
URI https://repositorio.unifesp.br/handle/11600/55646

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