Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems

Evaluation of survival of patients with hepatocellular carcinoma: A comparative analysis of prognostic systems

Author Tannus, Roberta Kazan Autor UNIFESP Google Scholar
Almeida-Carvalho, S. R. Autor UNIFESP Google Scholar
Matos, Carla Adriana Loureiro de Autor UNIFESP Google Scholar
Gonzalez, Adriano Miziara Autor UNIFESP Google Scholar
Salzedas-Netto, Alcides Augusto Autor UNIFESP Google Scholar
Szejnfeld, Denis Autor UNIFESP Google Scholar
D'Ippolito, Giuseppe Autor UNIFESP Google Scholar
Lanzoni, Valeria Pereira Autor UNIFESP Google Scholar
Souza-Silva, I. Autor UNIFESP Google Scholar
Abstract Background and aim There are several prognostic systems that address different aspects of the patient and the tumour and can guide the management of patients with hepatocellular carcinoma (HCC). This study aimed to evaluate and compare the eight staging systems for a group of patients in a public service in Brazil. Methods Patients with HCC were retrospectively analysed between 2000 and 2012. The prognostic systems Okuda, The Cancer of the Liver Italian Program (CLIP), the Chinese University Prognostic Index (CUPI), Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire (GRETCH), the modified TNM-based Japan Integrated Score (JIS) combined with alpha-fetoprotein and Child-Turcotte-Pugh (CTP), the TNM system, and the Barcelona Clinic Liver Cancer Classification (BCLC) were applied to these patients and compared through model fit measurements, likelihood scores, and the Akaike Information Criterion (AIC). Results A total of 247 patients were studied. The average survival time was 60 months. The TNM, Okuda, CLIP, GRETCH, modified JIS, and BCLC systems were well correlated with one another and individually important to the prediction of survival among the patients studied. However, in the statistical analysis, the CUPI delivered the best predictive performance (AIC = 566

log-likelihood =-281,240). Conclusion Although the CUPI system was demonstrated to be the most appropriate HCC staging system for the studied population, the choice of an ideal system is a controversial subject, andfuture studies with larger numbers of patients are necessary for the validation of the CUPI system as the method of choice for other populations.
xmlui.dri2xhtml.METS-1.0.item-coverage San Francisco
Language English
Date 2018
Published in Plos One. San Francisco, v. 13, n. 4, p. -, 2018.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent -
Origin http://dx.doi.org/10.1371/journal.pone.0194922
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000429203800056
URI https://repositorio.unifesp.br/handle/11600/55645

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