Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway

Cytokine Kinetics in Febrile Neutropenic Children: Insights on the Usefulness as Sepsis Biomarkers, Influence of Filgrastim, and Behavior of the IL-23/IL-17 Pathway

Author de Araujo, Orlei Ribeiro Autor UNIFESP Google Scholar
Salomao, Reinaldo Autor UNIFESP Google Scholar
Colo Brunialti, Milena Karina Autor UNIFESP Google Scholar
Bourguignon da Silva, Dafne Cardoso Autor UNIFESP Google Scholar
Senerchia, Andreza Almeida Autor UNIFESP Google Scholar
de Moraes Costa Carlesse, Fabianne Altruda Autor UNIFESP Google Scholar
Petrilli, Antonio Sergio Autor UNIFESP Google Scholar
Abstract Background. The study aimed to describe the kinetics of various cytokines from day 1 to day 14 of the onset of fever in neutropenic children and to evaluate their performances as discriminators of sepsis in the first 24 hours of fever, the possible influence of filgrastim, and the functioning of the IL-23/IL-17 axis. Methods. IL-1 beta, TNF-alpha, IL-10, IL-12/23p40, IL-21, IL-6, IL-8, IL-17, G-CSF, and GM-CSF were measured in plasma on days 1, 2, 3, 5, and 14 from the onset of fever in 35 patients. Results. Thirteen patients (37.1%) developed sepsis. In mixed models, IL-6, IL-8, IL-10, and G-CSF showed higher estimated means in septic patients (P < 0 005), and IL-12/23p40 and IL-17 in nonseptic patients (P < 0 05). On day 1, IL-6, IL-8, and IL-10 appeared upregulated in patients who received filgrastim. Only IL-6, IL-8, IL-10, and procalcitonin were useful as discriminators of sepsis. Associating the markers with each other or to a risk assessment model improved performance. Conclusions. Cytokines kinetics showed proinflammatory and anti-inflammatory responses similar to what is described in nonneutropenic patients. IL-8, IL-6, IL-10, and procalcitonin are useful as early biomarkers of sepsis. Filgrastim upregulates expression of these markers, and we observed deficiency in the IL-23-IL-17 axis accompanying sepsis.
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
GRAACC/Instituto de Oncologia Pediatrica
Grant number FAPESP: 2011/20401-4
Date 2017
Published in Mediators Of Inflammation. London, v. , p. -, 2017.
ISSN 0962-9351 (Sherpa/Romeo, impact factor)
Publisher Hindawi Ltd
Extent -
Origin http://dx.doi.org/10.1155/2017/8291316
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000405598300001
URI https://repositorio.unifesp.br/handle/11600/55518

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