Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis

Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis

Autor Pereira Junior, Jose Carlos Google Scholar
Pradella-Hallinan, Márcia Lurdes de Cássia Autor UNIFESP Google Scholar
Pessoa, Hugo de Lins Google Scholar
Instituição Faculdade de Medicina de Jundiaí Departamento de Pediatria
Universidade Federal de São Paulo (UNIFESP)
Resumo Data collected from medical literature indicate that dopaminergic agonists alleviate Restless Legs Syndrome symptoms while dopaminergic agonists antagonists aggravate them. Dopaminergic agonists is a physiological regulator of thyroid-stimulating hormone. Dopaminergic agonists infusion diminishes the levels of thyroid hormones, which have the ability to provoke restlessness, hyperkinetic states, tremors, and insomnia. Conditions associated with higher levels of thyroid hormones, such as pregnancy or hyperthyroidism, have a higher prevalence of Restless Legs Syndrome symptoms. Low iron levels can cause secondary Restless Legs Syndrome or aggravate symptoms of primary disease as well as diminish enzymatic activities that are involved in dopaminergic agonists production and the degradation of thyroid hormones. Moreover, as a result of low iron levels, dopaminergic agonists diminishes and thyroid hormones increase. Iron therapy improves Restless Legs Syndrome symptoms in iron deprived patients. Medical hypothesis. To discuss the theory that thyroid hormones, when not counterbalanced by dopaminergic agonists, may precipitate the signs and symptoms underpinning Restless Legs Syndrome. The main cause of Restless Legs Syndrome might be an imbalance between the dopaminergic agonists system and thyroid hormones.
Palavra-chave Restless Legs Syndrome
RLS
RLS pathophysiology
Dopamine
TSH
CYP450
Idioma Inglês
Data de publicação 2010-01-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 65, n. 5, p. 547-554, 2010.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
Publicador Faculdade de Medicina / USP
Extensão 547-554
Fonte http://dx.doi.org/10.1590/S1807-59322010000500013
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000278959900013
SciELO S1807-59322010000500013 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/5536

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