Human hypocretin-deficient narcolepsy - aberrant food choice due to impaired taste?

Human hypocretin-deficient narcolepsy - aberrant food choice due to impaired taste?

Author Truzzi, Giselle de Martin Autor UNIFESP Google Scholar
Cremaschi, Renata Carvalho Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Coelho, Fernando Morgadinho Autor UNIFESP Google Scholar
Abstract Authors demonstrate that patients with narcolepsy type 1 (N1) have more tendency of eat salty snacks after satiety than health volunteers. A few mechanisms to explain the weight gain have been discussed in narcolepsy. The hypocretin-1 deficiency can influence the olfactory system. The olfactory system should be modulated through hypocretin-1 via connections from the hypothalamic to other brain regions. Likewise, hypocretin-1 can be synthesized locally in our olfactory mucosa with possible private role modulating the olfactory. In experimental studies, different kinds of smell influence the preference for type of diet. Olfactory and taste sensations help control of appetite and regulate the quantity and quality of foods that will be chosen. N1 patients have lower levels of hypocretin-1 and consequent inferior olfactory threshold, less olfactory discrimination, and these findings improved after nasal hypocretin-1 administration. It is possible that the hyposmia influenced the quality and quantity of food by narcoleptic patients. We suggest that a complementary analysis of olfactory function should be done concomitant with food preferences to compare narcoleptic patients with and without hypocretin-1 deficiency.
Keywords Narcolepsy
Hypocretin-1
Obesity
Olfaction
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Date 2017
Published in Sleep Science. Amsterdam, v. 10, n. 2, p. 78-79, 2017.
ISSN 1984-0659 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 78-79
Origin https://doi.org/10.5935/1984-0063.20170014
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000418884200005
URI https://repositorio.unifesp.br/handle/11600/55358

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