M1 muscarinic receptors are necessary for retrieval of remote context fear memory

M1 muscarinic receptors are necessary for retrieval of remote context fear memory

Author Patricio, Rafael Rodisanski Autor UNIFESP Google Scholar
Kramer Soares, Juliana Carlota Autor UNIFESP Google Scholar
Menezes Oliveira, Maria Gabriela Autor UNIFESP Google Scholar
Abstract Several studies have investigated the transition of consolidation of recent memory to remote memory in aversively motivated tasks, such as contextual fear conditioning (CFC) and inhibitory avoidance (IA). However, the mechanisms that serve the retrieval of remote memories, has not yet been fully understood. Some evidences suggest that the central cholinergic system appears be involved in the modulation of these processes. Therefore, the present study aimed to investigate the effects of a pre-test administration of dicyclomine, a high-affinity M1 muscarinic receptor antagonist, on the retrieval of remote memories in fear conditioning and IA tasks. Male Wistar rats were trained, and after 1 or 28 days, the rats received dicyclomine (16 or 32 mg/lcg, intraperitoneally, i.p.) and were tested in CFC, tone fear conditioning (TFC) and IA tasks. At both time intervals, 32 mg/kg dicydomine induced impairment of CFC. In TFC task only the performance of the rats 28 days after training was impaired. The IA task was not affected in any of the studied intervals. These findings suggest a differential contribution of muscarinic receptors on recent and remote memories retrieval revealing a more generalized role in remote memory. (C) 2016 Elsevier Inc. All rights reserved.
Keywords Fear conditioning
Inhibitory avoidance
Memory retrieval
Remote memory
Ml receptor
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Sao Paulo Research Foundation (FAPESP)
Research Incentive Fund Association (Associacao Fundo de Incentivo a Pesquisa - AFIP)
Coordination for the Improvement of Higher Education Personnel (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES)
National Council of Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq)
Grant number FAPESP: 2009/12871-0
Date 2017
Published in Physiology & Behavior. Oxford, v. 169, p. 202-207, 2017.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 202-207
Origin http://dx.doi.org/10.1016/j.physbeh.2016.12.008
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000392774100028
URI https://repositorio.unifesp.br/handle/11600/55215

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