Development of electroactive nanofibers based on thermoplastic polyurethane and poly(o-ethoxyaniline) for biological applications

Development of electroactive nanofibers based on thermoplastic polyurethane and poly(o-ethoxyaniline) for biological applications

Author Noronha Cruz, Karina Ferreira Autor UNIFESP Google Scholar
Ducatti Formaggio, Daniela Maria Autor UNIFESP Google Scholar
Tada, Dayane Batista Autor UNIFESP Google Scholar
Cristovan, Fernando Henrique Autor UNIFESP Google Scholar
Guerrini, Lilia Mueller Autor UNIFESP Google Scholar
Abstract Electroactive nanofibers based on thermoplastic polyurethane (TPU) and poly(alkoxy anilines) produced by electrospinning has been explored for biomaterials applications. The thermoplastic polyurethane is a biocompatible polymer with good mechanical properties. The production of TPU nanofibers requires the application of high voltage during electrospinning in order to prepare uniform mats due to its weak ability to elongate during the process. To overcome this limitation, a conductive polymer can be incorporated to the process, allowing generates mats without defects. In this study, poly(o-ethoxyaniline) POEA doped with dodecylbenzene sulfonic acid (DBSA) was blended with thermoplastic polyurethane (TPU) by solution method. Films were produced by casting and nanofibers were prepared by electrospinning. The effect of the POEA on morphology, distribution of diameter and cell viability of the nanofibers was evaluated. The results demonstrated that the incorporation of POEA in TPU provided to the mats a suitable morphology for cellular growth. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 601-607, 2017.
Keywords electrospinning
poly(o-ethoxyaniline)
thermoplastic polyurethane
cell viability
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor CNPq
FAPESP
Date 2017
Published in Journal Of Biomedical Materials Research Part A. Hoboken, v. 105, n. 2, p. 601-607, 2017.
ISSN 1549-3296 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 601-607
Origin http://dx.doi.org/10.1002/jbm.a.35928
Access rights Closed access
Type Article
Web of Science ID WOS:000392506300025
URI https://repositorio.unifesp.br/handle/11600/55214

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account