The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes

The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes

Author Nunes, Rafael Almeida Autor UNIFESP Google Scholar
Mazzotti, Diego Robles Autor UNIFESP Google Scholar
Hirotsu, Camila Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Bittencourt, Lia Autor UNIFESP Google Scholar
Abstract Objective: To verify the association between c.1083T>C polymorphism in the adenosine receptor A2A gene (ADORA2A) and objective sleep, as well as the correlation between caffeine consumption, sleep parameters, and electroencephalographic spectral power in a large, population-based sample from Sao Paulo, Brazil. Methods: This study was conducted in participants of the Sao Paulo Epidemiologic Sleep Study (EPISONO), a large, population-based survey consisting of a representative sample of the inhabitants of the city from Sao Paulo, Brazil, according to sex, age (20-80 years), and socioeconomic status in the year 2007. Questionnaires, polysomnography, spectral analysis of sleep electroencephalogram, and c.1083T>C polymorphism genotyping were performed in this study. Results: We found that caffeine consumption was positively correlated with sleep latency and a spectral power, as well as negatively correlated with percentage of N3 stage and delta spectral power in this stage. However, this association was identified only in T allele carriers and not in CC genotype. Conclusion: Our data support an important aspect of this polymorphism in ADORA2A gene, showing that the variant affects the association between caffeine consumption and objective sleep parameters in a large population-based cohort. (C) 2016 Elsevier B.V. All rights reserved.
Keywords Sleep
Adenosine receptor
Caffeine intake
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Sao Paulo Research Foundation (FAPESP)
Coordencao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Grant number FAPESP: 1998/14303-3
Date 2017
Published in Sleep Medicine. Amsterdam, v. 30, p. 210-215, 2017.
ISSN 1389-9457 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 210-215
Access rights Closed access
Type Article
Web of Science ID WOS:000396883200037

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