Adults with Initial Metabolic Syndrome have Altered Muscle Deoxygenation During Incremental Exercise

Adults with Initial Metabolic Syndrome have Altered Muscle Deoxygenation During Incremental Exercise

Author Machado, Alessandro da Costa Google Scholar
Barbosa, Thales Coelho Google Scholar
Kluser Sales, Allan Robson Google Scholar
de Souza, Marcio Nogueira Google Scholar
Lucas da Nobrega, Antonio Claudio Google Scholar
Silva, Bruno Moreira Autor UNIFESP Google Scholar
Abstract Objective: Reduced aerobic power is independently associated with metabolic syndrome ( MetS) incidence and prevalence in adults. This study investigated whether muscle deoxygenation ( proxy of microvascular O-2 extraction) during incremental exercise is altered in MetS and associated with reduced oxygen consumption ( (V) over dotO(2peak)). Methods: Twelve men with initial MetS ( no overt diseases and medication-naive

mean+/-SD, age 38+/-7 years) and 12 healthy controls ( HCs) ( 34+/-7 years) completed an incremental cycling test to exhaustion, in which pulmonary ventilation and gas exchange ( metabolic analyzer), as well as vastus lateralis deoxygenation ( near infrared spectroscopy), were measured. Results: Subjects with MetS, in contrast to HCs, showed lower (V) over dotO(2peak) normalized to total lean mass, similar (V) over dotO(2peak) response to exercise, and earlier break point ( BP) in muscle deoxygenation. Consequently, deoxygenation slope from BP to peak exercise was greater. Furthermore, absolute (V) over dotO(2peak) was positively associated with BP in correlations adjusted for total lean mass. Conclusions: MetS, without overt diseases, altered kinetics of muscle deoxygenation during incremental exercise, particularly at high-intensity exercise. Therefore, the balance between utilization and delivery of O-2 within skeletal muscle is impaired early in MetS natural history, which may contribute to the reduction in aerobic power.
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor National Council for Scientific and Technological Development (CNPq)
Foundation of Research Support of Rio de Janeiro State (FAPERJ)
Grant number CNPq: PRONEX - 17/2009
FAPERJ: E-26/102.378/2009
Date 2017
Published in Obesity. Hoboken, v. 25, n. 2, p. 424-431, 2017.
ISSN 1930-7381 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 424-431
Access rights Closed access
Type Article
Web of Science ID WOS:000394970100027

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