Exploring the genomic diversity of black yeasts and relatives (Chaetothyriales, Ascomycota)

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dc.contributor.author Teixeira, M. M.
dc.contributor.author Moreno, L. F.
dc.contributor.author Stielow, B. J.
dc.contributor.author Muszewska, A.
dc.contributor.author Hainaut, M.
dc.contributor.author Gonzaga, L.
dc.contributor.author Abouelleil, A.
dc.contributor.author Patane, J. S. L.
dc.contributor.author Priest, M.
dc.contributor.author Souza, R.
dc.contributor.author Young, S.
dc.contributor.author Ferreira, K. S. [UNIFESP]
dc.contributor.author Zeng, Q.
dc.contributor.author da Cunha, M. M. L.
dc.contributor.author Gladki, A.
dc.contributor.author Barker, B.
dc.contributor.author Vicente, V. A.
dc.contributor.author de Souza, E. M.
dc.contributor.author Almeida, S.
dc.contributor.author Henrissat, B.
dc.contributor.author Vasconcelos, A. T. R.
dc.contributor.author Deng, S.
dc.contributor.author Voglmayr, H.
dc.contributor.author Moussa, T. A. A.
dc.contributor.author Gorbushina, A.
dc.contributor.author Felipe, M. S. S.
dc.contributor.author Cuomo, C. A.
dc.contributor.author de Hoog, G. Sybren
dc.date.accessioned 2020-07-17T14:02:41Z
dc.date.available 2020-07-17T14:02:41Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1016/j.simyco.2017.01.001
dc.identifier.citation Studies In Mycology. Utrecht, v. , n. 86, p. 1-28, 2017.
dc.identifier.issn 0166-0616
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/54944
dc.description.abstract The order Chaetothyriales (Pezizomycotina, Ascomycetes) harbours obligatorily melanised fungi and includes numerous etiologic agents of chromoblastomycosis, phaeohyphomycosis and other diseases of vertebrate hosts. Diseases range from mild cutaneous to fatal cerebral or disseminated infections and affect humans and cold-blooded animals globally. In addition, Chaetothyriales comprise species with aquatic, rock-inhabiting, ant-associated, and mycoparasitic life-styles, as well as species that tolerate toxic compounds, suggesting a high degree of versatile extremotolerance. To understand their biology and divergent niche occupation, we sequenced and annotated a set of 23 genomes of main the human opportunists within the Chaetothyriales as well as related environmental species. Our analyses included fungi with diverse life-styles, namely opportunistic pathogens and closely related saprobes, to identify genomic adaptations related to pathogenesis. Furthermore, ecological preferences of Chaetothyriales were analysed, in conjuncture with the order-level phylogeny based on conserved ribosomal genes. General characteristics, phylogenomic relationships, transposable elements, sex-related genes, protein family evolution, genes related to protein degradation (MEROPS), carbohydrate-active enzymes (CAZymes), melanin synthesis and secondary metabolism were investigated and compared between species. Genome assemblies varied from 25.81 Mb (Capronia coronata) to 43.03 Mb (Cladophialophora immunda). The bantiana-clade contained the highest number of predicted genes (12 817 on average) as well as larger genomes. We found a low content of mobile elements, with DNA transposons from Tc1/Mariner superfamily being the most abundant across analysed species. Additionally, we identified a reduction of carbohydrate degrading enzymes, specifically many of the Glycosyl Hydrolase (GH) class, while most of the Pectin Lyase (PL) genes were lost in etiological agents of chromoblastomycosis and phaeohyphomycosis. An expansion was found in protein degrading peptidase enzyme families S12 (serine-type D-Ala-D-Ala carboxypeptidases) and M38 (isoaspartyl dipeptidases). Based on genomic information, a wide range of abilities of melanin biosynthesis was revealed en
dc.description.abstract genes related to metabolically distinct DHN, DOPA and pyomelanin pathways were identified. The MAT (MAting Type) locus and other sex-related genes were recognized in all 23 black fungi. Members of the asexual genera Fonsecaea and Cladophialophora appear to be heterothallic with a single copy of either MAT-1-1 or MAT-1-2 in each individual. All Capronia species are homothallic as both MAT1-1 and MAT1-2 genes were found in each single genome. The genomic synteny of the MAT-locus flanking genes (SLA2-APN2-COX13) is not conserved in black fungi as is commonly observed in Eurotiomycetes, indicating a unique genomic context for MAT in those species. The heterokaryon (het) genes expansion associated with the low selective pressure at the MAT-locus suggests that a parasexual cycle may play an important role in generating diversity among those fungi. en
dc.description.sponsorship National Institute of Science and Technology of Nitrogen Fixation/CNPq/MCT
dc.description.sponsorship Fundacao Araucaria
dc.description.sponsorship National Human Genome Research Institute
dc.description.sponsorship CNPq/FAP-DF
dc.description.sponsorship CAPES-Brazil
dc.description.sponsorship King Abdulaziz University, Jeddah
dc.description.sponsorship DSR
dc.description.sponsorship National Science Centre (Poland)
dc.description.sponsorship LNCC
dc.format.extent 1-28
dc.language.iso eng
dc.publisher Centraalbureau Schimmelculture
dc.relation.ispartof Studies In Mycology
dc.rights Acesso aberto
dc.subject Black yeast en
dc.subject Comparative genomics en
dc.subject Chaetothyriales en
dc.subject Ecology en
dc.subject Evolution en
dc.subject Herpotrichiellaceae en
dc.subject Phylogeny en
dc.title Exploring the genomic diversity of black yeasts and relatives (Chaetothyriales, Ascomycota) en
dc.type Artigo
dc.description.affiliation Translat Genom Res Inst TGen, Div Pathogen Gen, Flagstaff, AZ USA
dc.description.affiliation Univ Brasilia, Dept Cell Biol, Brasilia, DF, Brazil
dc.description.affiliation Westerdijk Fungal Biodivers Inst, Utrecht, Netherlands
dc.description.affiliation Polish Acad Sci, Inst Biochem & Biophys, Warsaw, Poland
dc.description.affiliation Univ Aix Marseille, CNRS, Marseille, France
dc.description.affiliation Natl Lab Sci Comp LNCC, Petropolis, Brazil
dc.description.affiliation Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
dc.description.affiliation Univ Sao Paulo, Dept Biochem, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Biol Sci, Diadema, SP, Brazil
dc.description.affiliation Univ Fed Rio de Janeiro, Nucleo Multidisciplinar Pesquisa Biol UFRJ Xerem, Rio De Janeiro, Brazil
dc.description.affiliation Univ Fed Parana, Dept Basic Pathol, Curitiba, PR, Brazil
dc.description.affiliation Univ Fed Parana, Dept Biochem & Mol Biol, Curitiba, PR, Brazil
dc.description.affiliation Univ Sao Paulo, Dept Clin & Toxicol Anal, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
dc.description.affiliation Second Mil Med Univ, Shanghai Inst Med Mycol, Changzheng Hosp, Shanghai, Peoples R China
dc.description.affiliation niv Vienna, Dept Systemat & Evolutionary Bot, Vienna, Austria
dc.description.affiliation King Abdulaziz Univ, Fac Sci, Biol Sci Dept, Jeddah, Saudi Arabia
dc.description.affiliation Cairo Univ, Fac Sci, Bot & Microbiol Dept, Giza, Egypt
dc.description.affiliation BAM Fed Inst Mat Res & Testing, Berlin, Germany
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Biol Sci, Diadema, SP, Brazil
dc.description.sponsorshipID National Institute of Science and Technology of Nitrogen Fixation/CNPq/MCT: 573828/2008-3
dc.description.sponsorshipID National Human Genome Research Institute: U54HG003067
dc.description.sponsorshipID CNPq/FAP-DF: 193000569/2009
dc.description.sponsorshipID CAPES: 1331-13-2
dc.description.sponsorshipID King Abdulaziz University, Jeddah: 30-130-36-RG
dc.description.sponsorshipID National Science Centre (Poland): 2012/07/D/NZ2/04286
dc.identifier.file WOS000411880700001.pdf
dc.identifier.doi 10.1016/j.simyco.2017.01.001
dc.description.source Web of Science
dc.identifier.wos WOS:000411880700001
dc.coverage Utrecht
dc.citation.issue 86


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