Epilepsy and exercise: An experimental study in female rats

Epilepsy and exercise: An experimental study in female rats

Author Campos, Diego Vannucci Autor UNIFESP Google Scholar
Lopim, Glauber Menezes Autor UNIFESP Google Scholar
da Silva, Daiana Aparecida Autor UNIFESP Google Scholar
de Almeida, Alexandre Aparecido Autor UNIFESP Google Scholar
Amado, Debora Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Abstract Objective: Epilepsy is the most common neurological chronic condition worldwide, affecting about 2% of world population. Temporal lobe epilepsy (TLE) reaches 40% of all cases of this condition, and it is highly refractory to pharmacological treatment. Physical activity has been suggested as complementary therapy for epilepsy. However, there is no consistent information whether all these effects are plenty applicable to females, since clinical and experimental studies concerning physical exercise and epilepsy are largely performed in males. Females are worthy of special attention due to gender specific particularities such as hormonal cyclical rhythm and possible pregnancy. Therefore, this study aimed to investigate the impact of two types of exercise programs (Forced and Voluntary) in female Wistar rats submitted to temporal lobe epilepsy induced by pilocarpine. Methods: Animals were divided into four groups: Control (healthy), Epilepsy, Epilepsy/Forced (exercise in a treadmill) and Epilepsy/Voluntary (free access to wheel). Behavioral and histological analyses were evaluated among groups. Results: Voluntary exercise was able to reduce seizure frequency and anovulatory estrous cycle occurrence. Yet, both types of exercise attenuated the mossy fiber sprouting in dentate gyrus. Conclusion: Our results indicate that voluntary exercise exerts a positive effect on epilepsy in female gender. Further investigations are necessary to better elucidate mechanisms involved in these responses, since these effects do not act in the same manner in male and female rats. (C) 2017 Elsevier Inc All rights reserved.
Keywords Epilepsy
Exercise
Female
Estrous cycle
Rats
Hormones
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Date 2017
Published in Physiology & Behavior. Oxford, v. 171, p. 120-126, 2017.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 120-126
Origin http://dx.doi.org/10.1016/j.physbeh.2016.12.040
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000394076100016
URI https://repositorio.unifesp.br/handle/11600/54927

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