Anti-hypertensive drugs have different effects on ventricular hypertrophy regression

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dc.contributor.author Ferreira Filho, Celso [UNIFESP]
dc.contributor.author Abreu, Luiz Carlos de
dc.contributor.author Valenti, Vitor Engrácia [UNIFESP]
dc.contributor.author Ferreira, Marcelo
dc.contributor.author Meneghini, Adriano
dc.contributor.author Silveira, José Alexandre
dc.contributor.author Perez Riera, Andrés Ricardo [UNIFESP]
dc.contributor.author Colombari, Eduardo [UNIFESP]
dc.contributor.author Murad, Neif
dc.contributor.author Santos-Silva, Paulo Roberto
dc.contributor.author Silva, Lovian José Henrique Pereira da
dc.contributor.author Vanderlei, Luiz Carlos Marques
dc.contributor.author Carvalho, Tatiana Dias de [UNIFESP]
dc.contributor.author Ferreira, Celso [UNIFESP]
dc.date.accessioned 2015-06-14T13:41:24Z
dc.date.available 2015-06-14T13:41:24Z
dc.date.issued 2010-01-01
dc.identifier http://dx.doi.org/10.1590/S1807-59322010000700012
dc.identifier.citation Clinics. Faculdade de Medicina / USP, v. 65, n. 7, p. 723-728, 2010.
dc.identifier.issn 1807-5932
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/5488
dc.description.abstract OBJECTIVES: There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature. METHODS: The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy. RESULTS: The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective β1 receptor antagonist) with respect to LVH regression. CONCLUSION: The anti-hypertensive drugs induced various degrees of hypertrophic regression. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Nucleo de Estudos, Pesquisas e Assessoria a Saude da Faculdade de Medicina do ABC (NEPAS)
dc.format.extent 723-728
dc.language.iso eng
dc.publisher Faculdade de Medicina / USP
dc.relation.ispartof Clinics
dc.rights Acesso aberto
dc.subject Hypertrophy en
dc.subject Cardiomyopathy en
dc.subject Hypertrophic en
dc.subject Left ventricle hypertension en
dc.subject Cardiology en
dc.title Anti-hypertensive drugs have different effects on ventricular hypertrophy regression en
dc.type Artigo
dc.contributor.institution Faculdade de Medicina do ABC Disciplina de Cardiologia Departamento de Clínica Médica
dc.contributor.institution Faculdade de Medicina do ABC Departamento de Morfologia e Fisiologia
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Estadual Paulista (UNESP)
dc.description.affiliation Faculdade de Medicina do ABC Disciplina de Cardiologia Departamento de Clínica Médica
dc.description.affiliation Faculdade de Medicina do ABC Departamento de Morfologia e Fisiologia
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Disciplina de Cardiologia Departamento de Medicina
dc.description.affiliation Universidade Estadual Paulista Faculdade de Ciências e Tecnologia Departamento de Fisioterapia
dc.description.affiliationUnifesp UNIFESP, Disciplina de Cardiologia Depto. de Medicina
dc.identifier.file S1807-59322010000700012.pdf
dc.identifier.scielo S1807-59322010000700012
dc.identifier.doi 10.1590/S1807-59322010000700012
dc.description.source SciELO
dc.identifier.wos WOS:000280808400012



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