Anti-hypertensive drugs have different effects on ventricular hypertrophy regression

Anti-hypertensive drugs have different effects on ventricular hypertrophy regression

Autor Ferreira Filho, Celso Autor UNIFESP Google Scholar
Abreu, Luiz Carlos de Google Scholar
Valenti, Vitor Engrácia Autor UNIFESP Google Scholar
Ferreira, Marcelo Google Scholar
Meneghini, Adriano Google Scholar
Silveira, José Alexandre Google Scholar
Perez Riera, Andrés Ricardo Autor UNIFESP Google Scholar
Colombari, Eduardo Autor UNIFESP Google Scholar
Murad, Neif Google Scholar
Santos-Silva, Paulo Roberto Google Scholar
Silva, Lovian José Henrique Pereira da Google Scholar
Vanderlei, Luiz Carlos Marques Google Scholar
Carvalho, Tatiana Dias de Autor UNIFESP Google Scholar
Ferreira, Celso Autor UNIFESP Google Scholar
Instituição Faculdade de Medicina do ABC Disciplina de Cardiologia Departamento de Clínica Médica
Faculdade de Medicina do ABC Departamento de Morfologia e Fisiologia
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual Paulista (UNESP)
Resumo OBJECTIVES: There is a direct relationship between the regression of left ventricular hypertrophy (LVH) and a decreased risk of mortality. This investigation aimed to describe the effects of anti-hypertensive drugs on cardiac hypertrophy through a meta-analysis of the literature. METHODS: The Medline (via PubMed), Lilacs and Scielo databases were searched using the subject keywords cardiac hypertrophy, antihypertensive and mortality. We aimed to analyze the effect of anti-hypertensive drugs on ventricle hypertrophy. RESULTS: The main drugs we described were enalapril, verapamil, nifedipine, indapamina, losartan, angiotensin-converting enzyme inhibitors and atenolol. These drugs are usually used in follow up programs, however, the studies we investigated used different protocols. Enalapril (angiotensin-converting enzyme inhibitor) and verapamil (Ca++ channel blocker) caused hypertrophy to regress in LVH rats. The effects of enalapril and nifedipine (Ca++ channel blocker) were similar. Indapamina (diuretic) had a stronger effect than enalapril, and losartan (angiotensin II receptor type 1 (AT1) receptor antagonist) produced better results than atenolol (selective β1 receptor antagonist) with respect to LVH regression. CONCLUSION: The anti-hypertensive drugs induced various degrees of hypertrophic regression.
Palavra-chave Hypertrophy
Cardiomyopathy
Hypertrophic
Left ventricle hypertension
Cardiology
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Nucleo de Estudos, Pesquisas e Assessoria a Saude da Faculdade de Medicina do ABC (NEPAS)
Data de publicação 2010-01-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 65, n. 7, p. 723-728, 2010.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
Publicador Faculdade de Medicina / USP
Extensão 723-728
Fonte http://dx.doi.org/10.1590/S1807-59322010000700012
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000280808400012
SciELO S1807-59322010000700012 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/5488

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