Gut Microbiome in Chronic Kidney Disease

Gut Microbiome in Chronic Kidney Disease

Author Armani, R. G. Autor UNIFESP Google Scholar
Ramezani, A. Google Scholar
Yasir, A. Google Scholar
Sharama, S. Google Scholar
Canziani, M. E. F. Autor UNIFESP Google Scholar
Raj, D. S. Google Scholar
Abstract With over 100 trillion microbial cells, the gut microbiome plays important roles in both the maintenance of health and the pathogenesis of disease. Gut microbiome dysbiosis, resulted from alteration of composition and function of the gut microbiome and disruption of gut barrier function, is commonly seen in patients with chronic kidney disease (CKD). The dysbiotic gut microbiome generates excessive amounts of uremic toxins, and the impaired intestinal barrier permits translocation of these toxins into the systemic circulation. Many of these uremic toxins have been implicated in the progression of CKD and increased cardiovascular risk. Various therapeutic interventions have been proposed that aim to restore gut microbiome symbiosis. If proven effective, these interventions will have a significant impact on the management of CKD patients. In this review, we discuss the consequences of gut microbiome dysbiosis in the context of CKD, discuss the consequences of gut dysbiosis, and highlight some of the recent interventions targeting the gut microbiome for therapeutic purposes.
Keywords Microbiome
Dysbiosis
Uremic toxin
Chronic kidney disease
Cardiovascular disease
xmlui.dri2xhtml.METS-1.0.item-coverage New York
Language English
Sponsor National Institutes of Health grant
Grant number National Institutes of Health grant: 1R01DK073665-01A1
National Institutes of Health grant: 1U01DK099924-01
National Institutes of Health grant: 1U01DK099914-01
Date 2017
Published in Current Hypertension Reports. New York, v. 19, n. 4, p. -, 2017.
ISSN 1522-6417 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent -
Origin http://dx.doi.org/10.1007/s11906-017-0727-0
Access rights Closed access
Type Article
Web of Science ID WOS:000397929900006
URI https://repositorio.unifesp.br/handle/11600/54861

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