Selenium Status in Patients with Turner Syndrome: a Biochemical Assessment Related with Body Composition

Selenium Status in Patients with Turner Syndrome: a Biochemical Assessment Related with Body Composition

Author Pires, Liliane Viana Google Scholar
Siviero-Miachon, Adriana Aparecida Google Scholar
Spinola-Castro, Angela Maria Autor UNIFESP Google Scholar
Coelho Pimentel, Jose Alexandre Google Scholar
Nishimura, Luciana Sigueta Google Scholar
Maia, Carla Soraya Costa Google Scholar
Franciscato Cozzolino, Silvia Maria Google Scholar
Abstract Studies about selenium status in patients with Turner syndrome (TS) are non-existent in the literature. The aim of this study was to evaluate selenium status in patients with TS, while considering the different ages of the studied population and the relation with body composition. In total, 33 patients with TS were evaluated and grouped according to their developmental stages (children, adolescents, and adults). Selenium concentrations in their plasma, erythrocytes, urine, and nails were determined by using hydride generation atomic absorption spectrometry and erythrocyte glutathione peroxidase activity were measured by using Randox commercial kits. Additionally, height, weight, body fat percentage, waist circumference, and waist-height ratio were measured to characterize the patients. No differences in the selenium concentrations in the plasma, erythrocyte, urine, and nails or in the glutathione peroxidase activity were observed among the age groups (p > 0.05). The evaluated selenium levels were less than the established normal ones. The patients with larger waist circumference, body fat percentage, body mass index, and waist-height ratio showed lower glutathione peroxidase enzyme activity (p = 0.023). The present study shows that most patients with TS are deficient in selenium and that those with a greater accumulation of body fat have a lower GPx activity.
Keywords Turner syndrome
Selenium
Glutathione peroxidase
Nutritional status
Fat body
xmlui.dri2xhtml.METS-1.0.item-coverage Totowa
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Grant number FAPESP: 2007/53865-8
CNPq: 130252/2006-9
Date 2017
Published in Biological Trace Element Research. Totowa, v. 176, n. 2, p. 217-224, 2017.
ISSN 0163-4984 (Sherpa/Romeo, impact factor)
Publisher Humana Press Inc
Extent 217-224
Origin http://dx.doi.org/10.1007/s12011-016-0831-z
Access rights Closed access
Type Article
Web of Science ID WOS:000396260000001
URI https://repositorio.unifesp.br/handle/11600/54853

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