Sleep pattern and spectral analysis of caregiver-mothers of sons with Duchenne muscular dystrophy, and an examination of differences between carriers and non-carriers

Sleep pattern and spectral analysis of caregiver-mothers of sons with Duchenne muscular dystrophy, and an examination of differences between carriers and non-carriers

Author Nozoe, Karen Tieme Autor UNIFESP Google Scholar
Kim, Lenise Jihe Autor UNIFESP Google Scholar
Polesel, Daniel Ninello Autor UNIFESP Google Scholar
Hirotsu, Camila Autor UNIFESP Google Scholar
de Souza, Altay Lino Autor UNIFESP Google Scholar
Hachul, Helena Autor UNIFESP Google Scholar
Tufik, Sergio Brasil Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Moreira, Gustavo Antonio Autor UNIFESP Google Scholar
Abstract Objectives: Sleep is essential for physical and mental well-being. However, poor sleep is a common complaint among caregivers. The aim of the present study was to determine sleep patterns of caregiver-mothers (CM group) of sons with Duchenne muscular dystrophy (DMD) and also to examine the differences between non-carriers and carriers of the gene related to DMD within the CM group. Methods: Observational case-control study. Participants: The CM and control (CTRL) groups were matched for age, body mass index and social class. Polysomnography was conducted in a sleep laboratory for one night. The discrete fast Fourier transformation method was used to calculate the electroencephalogram (EEG) power spectrum for the entire night and sleep stages. Results: The CM group presented higher sleep latency and N3 sleep stage compared with the CTRL. When carrier and non-carrier CM subgroups were analyzed, increased sleep latency and time awake, as well as reduced sleep efficiency and N2, were observed in the carrier group. Regarding respiratory parameters, carriers demonstrated higher hypopnea index values compared with non-carriers. Spectral analysis showed that carriers compared with non-carrier DMD caregiver-mothers presented lower spectral power in fast waves, mainly beta, during REM sleep in some EEG derivations. Conclusions: There was an impairment of sleep pattern in the CM group compared with CTRL mothers

this was possibly associated with difficulty in initiating sleep. Being a DMD gene carrying caregiver further compromised some aspects of sleep microstructure during REM sleep. The data demonstrated the importance of sleep evaluation in caregiver-mothers, and the relationship between sleep and being a carrier of the gene associated with DMD, which was demonstrated as possibly impacting sleep quality. (C) 2016 Elsevier B.V. All rights reserved.
Keywords Caregiver
Mother
Duchenne muscular dystrophy
Carrier
Sleep
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Sao Paulo Research Foundation (FAPESP) [2014/08067-0, 2015/19136-5]
CNPq
Date 2017
Published in Sleep Medicine. Amsterdam, v. 32, p. 114-121, 2017.
ISSN 1389-9457 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 114-121
Origin http://dx.doi.org/10.1016/j.sleep.2016.11.020
Access rights Closed access
Type Article
Web of Science ID WOS:000400211300018
URI https://repositorio.unifesp.br/handle/11600/54810

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account