Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer's disease dementia

Associations of cerebrovascular metabolism genotypes with neuropsychiatric symptoms and age at onset of Alzheimer's disease dementia

Author de Oliveira, Fabricio F. Autor UNIFESP Google Scholar
Chen, Elizabeth S. Autor UNIFESP Google Scholar
Smith, Marilia C. Autor UNIFESP Google Scholar
Bertolucci, Paulo H. Autor UNIFESP Google Scholar
Abstract Objective: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer's disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs1 1669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121. Results: Considering 201 patients, only APOE-epsilon 4 carriers had earlier dementia onset in multiple correlations, as well as less apathy, more delusions, and more aberrant motor behavior. Both ACE polymorphisms were associated with less intense frontally mediated behaviors. Regarding LDLR variants, carriers of the A allele of rs1 1669576 had less anxiety and more aberrant motor behavior, whereas carriers of the A allele of rs5930 had less delusions, less anxiety, more apathy, and more irritability. CETP variants that included G alleles of I422V and TaqIB were mostly associated with less intense frontally mediated behaviors, while severely impaired carriers of the T allele of rs2695121 had more anxiety and more aberrant motor behavior. Conclusion: Though only APOE haplotypes affected AD onset, cerebrovascular metabolism genotypes were associated with differences in several neuropsychiatric manifestations of AD.
Keywords Alzheimer disease
dementia
cerebrovascular disorders
genetics
neuropsychiatry
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Sponsor Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
CAPES
FAPESP
Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Grant number CAPES: 1067/10
FAPESP: 2015/10109-5
Date 2017
Published in Revista Brasileira De Psiquiatria. Sao Paulo, v. 39, n. 2, p. 95-103, 2017.
ISSN 1516-4446 (Sherpa/Romeo, impact factor)
Publisher Assoc Brasileira Psiquiatria
Extent 95-103
Origin http://dx.doi.org/10.1590/1516-4446-2016-1991
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000403273400004
SciELO ID S1516-44462017000200095 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/54785

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