IMPROVING THE REPRODUCIBILITY OF MOTOR UNIT NUMBER INDEX

IMPROVING THE REPRODUCIBILITY OF MOTOR UNIT NUMBER INDEX

Author Escorcio-Bezerra, Marcio Luiz Autor UNIFESP Google Scholar
Bulle Oliveira, Acary Souza Autor UNIFESP Google Scholar
De Oliveira Braga, Nadia Iandoli Autor UNIFESP Google Scholar
Manzano, Gilberto Mastrocola Autor UNIFESP Google Scholar
Abstract Introduction: Reproducibility is an important aspect of any method intended to be a marker of disease progression. In this study we investigated approaches for improving motor unit number index (MUNIX) reproducibility. Methods: We used the intraclass correlation coefficient (ICC) and the coefficient of variation (CV) to study reproducibility in healthy subjects. We tested reproducibility between test and retest of a single MUNIX from 3 different muscles (S-MUNIX) and also of the mean of a set of 3 measurements from these same muscles (M-MUNIX). Results: M-MUNIX was more reproducible than S-MUNIX. The CV showed a greater improvement than the ICC in all 3 muscles. Conclusions: M-MUNIX may be a valuable approach for following motor unit loss, because it is more replicable than MUNIX. This may be especially relevant in amyotrophic lateral sclerosis patients, in whom MUNIX variability is higher than in healthy individuals.
Keywords ALS
coefficient of variation
intraclass correlation coefficient
motor unit
MUNIX
reproducibility
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Date 2017
Published in Muscle & Nerve. Hoboken, v. 55, n. 5, p. 635-638, 2017.
ISSN 0148-639X (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent 635-638
Origin http://dx.doi.org/10.1002/mus.25260
Access rights Closed access
Type Article
Web of Science ID WOS:000399708900007
URI https://repositorio.unifesp.br/handle/11600/54692

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