Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer

Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer

Author Cardoso-Coelho, Livio Portela Google Scholar
Borges, Rafael Soares Google Scholar
Alencar, Airlane Pereira Google Scholar
Cardoso-Campos-Verdes, Larysse Maira Google Scholar
da Silva-Sampai, Joao Paulo Google Scholar
Borges, Umbelina Soares Google Scholar
Gebrim, Luiz Henrique Autor UNIFESP Google Scholar
da Silva, Benedito Borges Google Scholar
Abstract The replacement of sentinel lymph node biopsy (SNB) by ultrasound-guided fine-needle aspiration (US-guided FNA) cytology of axillary lymph nodes is controversial, despite the simplicity and reduced cost of the latter. In the present study, US-guided FNA was performed in 27 patients with early-stage breast cancer for comparison with SNB. Data were analyzed by calculation of sample proportions. Tumor subtypes included invasive ductal carcinoma (85%), invasive lobular carcinoma (7%), and tubular and metaplastic carcinoma (4%). FNA had a sensitivity of 45%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 73%. Axillary lymph node cytology obtained by US guided-FNA in patients with breast cancer had a specificity similar to that of sentinel lymph node histopathology in the presence of axillary node metastases. However, when lymph node cytology is negative, it does not exclude the existence of metastatic implants, due to its low sensitivity in comparison to sentinel lymph node histopathology.
Keywords breast cancer
axillary lymph node
sentinel lymph node
fine-needle aspiration biopsy
xmlui.dri2xhtml.METS-1.0.item-coverage Athens
Language English
Date 2017
Published in Oncology Letters. Athens, v. 13, n. 5, p. 3299-3302, 2017.
ISSN 1792-1074 (Sherpa/Romeo, impact factor)
Publisher Spandidos Publ Ltd
Extent 3299-3302
Origin http://dx.doi.org/10.3892/ol.2017.5817
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000401129800062
URI https://repositorio.unifesp.br/handle/11600/54607

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