Bone mineral density and vitamin D concentration: the challenges in taking care of children and adolescents infected with HIV

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dc.contributor.author Carmo, Fabiana Bononi [UNIFESP]
dc.contributor.author Terreri, Maria Teresa [UNIFESP]
dc.contributor.author de Menezes Succi, Regina Celia [UNIFESP]
dc.contributor.author Beltrao, Suenia Vasconcelos [UNIFESP]
dc.contributor.author Tome Barbosa Gouvea, Aida de Fatima [UNIFESP]
dc.contributor.author Cruz Paulino, Erica Regina [UNIFESP]
dc.contributor.author Machado, Daisy Maria [UNIFESP]
dc.date.accessioned 2020-07-13T11:53:19Z
dc.date.available 2020-07-13T11:53:19Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1016/j.bjid.2017.03.005
dc.identifier.citation Brazilian Journal Of Infectious Diseases. Rio De Janeiro, v. 21, n. 3, p. 270-275, 2017.
dc.identifier.issn 1413-8670
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/54538
dc.description.abstract Background: The increase in life expectancy for patients living with human immunodeficiency virus (HIV) infection has resulted in health complications related to a chronic disease. Objectives: To evaluate the prevalence of bone mineral density (BMD) alterations and vitamin D concentrations in HIV-infected children and adolescents and to verify the variations in those parameters during a 12-month interval. Methods: A prospective cohort study with a dual period of evaluation was conducted in 57 patients perinatally HIV-infected and one patient with sexual abuse in early infancy. Demographic, anthropometric, pubertal stage, viral load, T CD4+ cell count and antiretroviral therapy were evaluated. Biochemical tests and total body (TB) and lumbar spine (L1-L4) bone density evaluations by dual X-ray absorptiometry (DXA) were performed. Calcium or vitamin D supplements were prescribed if reduction in BMD or deficiency for vitamin D was detected. Results: 58 patients (ages 5.4-18.3 years en
dc.description.abstract 60.3% girls) were included (T0) en
dc.description.abstract 55 patients were reevaluated after 12 (+/- 3) months (T1). Low bone mass for chronological age was found in 6/58 (10.4%) and 6/55(10.9%) patients at T0 and at T1, respectively. There was no statistical relationship between z-scores for BMD (BMD z-score) and the variables sex, fracture history, family history of osteoporosis, physical activity and pubertal stage. There was a relation between BMD z-score alterations for TB and HIV viral load at T1 (p = 0.016). There was no association between duration or classes of antiretroviral therapy and bone density. Themean value of vitamin D in T0 was 23.43 ng/mL +/- 2.015 and in T1 22.1ng/mL +/- 0.707 and considered insufficient levels for this population. Conclusion: Patients infected with HIV are at risk for BMD alterations and lower vitamin D serum concentrations en
dc.description.abstract both of these variables should be evaluated at routine examinations in order to improve both prevention and therapeutic planning. (C) 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. en
dc.description.sponsorship Fundacao de Auxilio a Pesquisa do Estado de Sao Paulo
dc.format.extent 270-275
dc.language.iso eng
dc.publisher Elsevier Brazil
dc.relation.ispartof Brazilian Journal Of Infectious Diseases
dc.rights Acesso aberto
dc.subject HIV en
dc.subject Antiretroviral en
dc.subject Infant en
dc.subject Diagnosis en
dc.subject Metabolism en
dc.subject Bonea en
dc.title Bone mineral density and vitamin D concentration: the challenges in taking care of children and adolescents infected with HIV en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Ctr Atendimento, Disciplina Infectol Pediat CEADIPe, Sao Paulo, SP, Brazil
dc.description.affiliation Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Setor Reumatol Pediat, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Ctr Atendimento, Disciplina Infectol Pediat CEADIPe, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo UNIFESP, Escola Paulista Med, Setor Reumatol Pediat, Sao Paulo, SP, Brazil
dc.description.sponsorshipID FAPESP: 2011/20882-2
dc.identifier.doi 10.1016/j.bjid.2017.03.005
dc.description.source Web of Science
dc.identifier.wos WOS:000404453600009
dc.coverage Rio De Janeiro
dc.citation.volume 21
dc.citation.issue 3



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