Body Mass Index and skin reactivity to histamine and Dermatophagoides pteronyssinus in children and adolescents followed in a pediatric allergy service

Body Mass Index and skin reactivity to histamine and Dermatophagoides pteronyssinus in children and adolescents followed in a pediatric allergy service

Author Franco, A. Keller Autor UNIFESP Google Scholar
Sarni, R. Oselka Autor UNIFESP Google Scholar
Mallozi, M. Carvalho Autor UNIFESP Google Scholar
Sole, D. Autor UNIFESP Google Scholar
Abstract Rationale. Recent data suggest that the nutritional status assessed by body mass index (BMI) is positively associated with skin reactivity to histamine in children. Objective. To study the relation between BMI and skin reactivity to histamine and Dermatophagoides pteronyssinus in allergic children and adolescents. Methods. The medical charts of patients attended in our outpatient clinic between 2013 and 2014 (n = 972) were evaluated. Only patients with asthma, allergic rhinitis or wheezing infants sensitized to at least one aeroallergen were selected: a total of 626 patients (6 months to 19 year-olds

60.1% male) were enrolled. Weight (kg), height (m), BMI (weight/height(2)), and the mean diameter of the wheals induced by histamine (10 mg/ml) and Dermatophagoides pteronyssinus in skin prick tests (SPT) were obtained. Skin index (SI

ratio of allergen-induced wheal diameter and corresponding histamine diameter) was also analyzed. Results. All patients had shown a mean wheal diameter of histamine greater than 1 mm. There was no increased skin reactivity to histamine with increasing BMI Z score (ZBMI). However, a significant correlation between BMI and the mean wheal of histamine was observed in patients < -1 ZBMI. Similar results were observed with Dermatophagoides pteronyssinus, (even considering the SI). Conclusions. We did not document interference of nutritional status (ZBMI) on the skin reactivity to histamine or Dermatophagoiodes pteronyssinus in atopic patients. Further investigation is required.
Keywords Allergic sensitization
histamine
skin index
skin prick tests
body mass index
xmlui.dri2xhtml.METS-1.0.item-coverage Fidenza
Language English
Date 2017
Published in European Annals Of Allergy And Clinical Immunology. Fidenza, v. 49, n. 3, p. 110-113, 2017.
ISSN 1764-1489 (Sherpa/Romeo, impact factor)
Publisher Mattioli 1885
Extent 110-113
Origin http://www.eurannallergyimm.com/cont/journals-articles/483/volume-body-mass-index-skin-reactivity.asp
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000407852600003
URI https://repositorio.unifesp.br/handle/11600/54510

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