Alternative Methods to Animal Studies for the Evaluation of Topical/Transdermal Drug Delivery Systems

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dc.contributor.author Junqueira Garcia, Maria Teresa [UNIFESP]
dc.contributor.author Lopes de Vasconcellos, Fabia Leal [UNIFESP]
dc.contributor.author Raffier, Chloe Patricia
dc.contributor.author Roberts, Michael Stephen
dc.contributor.author Grice, Jeffrey Ernest
dc.contributor.author Elizabeth Benson, Heather Ann
dc.contributor.author Leite-Silva, Vania Rodrigues [UNIFESP]
dc.date.accessioned 2020-07-08T13:09:54Z
dc.date.available 2020-07-08T13:09:54Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.2174/1568026618666180412153214
dc.identifier.citation Current Topics In Medicinal Chemistry. Sharjah, v. 18, n. 4, p. 287-299, 2018.
dc.identifier.issn 1568-0266
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/54282
dc.description.abstract It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past, animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative methods have been proposed for use in the development of topical and transdermal delivery systems which are often used in combination. We will review the current state of the art in alternative methods for topical and transdermal delivery systems development, including technologies that can assist in the characterization of skin penetration/ permeation studies. en
dc.format.extent 287-299
dc.language.iso eng
dc.publisher Bentham Science Publ Ltd
dc.relation.ispartof Current Topics In Medicinal Chemistry
dc.rights Acesso restrito
dc.subject Skin penetration en
dc.subject Drug delivery systems en
dc.subject Alternative methods en
dc.subject In vivo en
dc.subject Ex vivo en
dc.subject In silico en
dc.subject Skin permeation en
dc.title Alternative Methods to Animal Studies for the Evaluation of Topical/Transdermal Drug Delivery Systems en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil
dc.description.affiliation Univ Queensland, Diamantina Inst, Translat Res Inst, Therapeut Res Ctr, Brisbane, Qld, Australia
dc.description.affiliation Univ South Australia, Sch Pharm & Med Sci, Adelaide, SA, Australia
dc.description.affiliation Curtin Univ Technol, Curtin Hlth Innovat Res Inst, Sch Pharm & Biomed Sci, Perth, WA, Australia
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil
dc.identifier.doi 10.2174/1568026618666180412153214
dc.description.source Web of Science
dc.identifier.wos WOS:000433386800005
dc.coverage Sharjah
dc.citation.volume 18
dc.citation.issue 4



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