Alternative Methods to Animal Studies for the Evaluation of Topical/Transdermal Drug Delivery Systems

Alternative Methods to Animal Studies for the Evaluation of Topical/Transdermal Drug Delivery Systems

Author Junqueira Garcia, Maria Teresa Autor UNIFESP Google Scholar
Lopes de Vasconcellos, Fabia Leal Autor UNIFESP Google Scholar
Raffier, Chloe Patricia Google Scholar
Roberts, Michael Stephen Google Scholar
Grice, Jeffrey Ernest Google Scholar
Elizabeth Benson, Heather Ann Google Scholar
Leite-Silva, Vania Rodrigues Autor UNIFESP Google Scholar
Abstract It is critical to develop an effective understanding of the interaction between the drug, delivery system and skin in order to predict and assess skin penetration and permeation. Experimental models for the assessment of topical and transdermal delivery systems must permit evaluation of these complex interactions. Whilst in the past, animal models were commonly used, recent regulatory guidelines, based on 3R principles (refinement, reduction, replacement), encourage the rational use of animals. Alternative methods have been proposed for use in the development of topical and transdermal delivery systems which are often used in combination. We will review the current state of the art in alternative methods for topical and transdermal delivery systems development, including technologies that can assist in the characterization of skin penetration/ permeation studies.
Keywords Skin penetration
Drug delivery systems
Alternative methods
In vivo
Ex vivo
In silico
Skin permeation
xmlui.dri2xhtml.METS-1.0.item-coverage Sharjah
Language English
Date 2018
Published in Current Topics In Medicinal Chemistry. Sharjah, v. 18, n. 4, p. 287-299, 2018.
ISSN 1568-0266 (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 287-299
Origin http://dx.doi.org/10.2174/1568026618666180412153214
Access rights Closed access
Type Article
Web of Science ID WOS:000433386800005
URI https://repositorio.unifesp.br/handle/11600/54282

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