Long-term Potentiation Decay and Poor Long-lasting Memory Process in the Wild Rodents Proechimys from Brazil's Amazon Rainforest

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dc.contributor.author Guimaraes Marques, Marcia J. [UNIFESP]
dc.contributor.author Reyes-Garcia, Selvin Z. [UNIFESP]
dc.contributor.author Marques-Carneiro, Jose E.
dc.contributor.author Lopes-Silva, Leonardo B. [UNIFESP]
dc.contributor.author Andersen, Monica L. [UNIFESP]
dc.contributor.author Cavalheiro, Esper A. [UNIFESP]
dc.contributor.author Scorza, Fulvio A. [UNIFESP]
dc.contributor.author Scorza, Carla A. [UNIFESP]
dc.date.accessioned 2020-07-08T13:09:51Z
dc.date.available 2020-07-08T13:09:51Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.3389/fnbeh.2018.00002
dc.identifier.citation Frontiers In Behavioral Neuroscience. Lausanne, v. 12, p. -, 2018.
dc.identifier.issn 1662-5153
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/54253
dc.description.abstract Proechimys are small terrestrial rodents from Amazon rainforest. Each animal species is adapted to a specific environment in which the animal evolved therefore without comparative approaches unique characteristics of distinct species cannot be fully recognized. Laboratory rodents are exceedingly inbred strains dissociated from their native habitats and their fundamental ecological aspects are abstracted. Thus, the employment of exotic non-model species can be informative and complement conventional animal models. With the aim of promoting comparative studies between the exotic wildlife populations in the laboratory and traditional rodent model, we surveyed a type of synaptic plasticity intimately related to memory encoding in animals. Using theta-burst paradigm, in vitro long-term potentiation (LTP) in the CA1 subfield of hippocampal slices was assessed in the Amazon rodents Proechimys and Wistar rats. Memory, learning and anxiety were investigated through the plus-maze discriminative avoidance task (PM-DAT) and object recognition test. In PM-DAT, both animal species were submitted to two test sessions (3-h and 24-h) after the conditioning training. Proechimys exhibited higher anxiety-like behavior in the training session but during test sessions both species exhibited similar patterns of anxiety-related behavior. After 3-h of the training, Proechimys and Wistar spent significantly less time in the aversive enclosed arm than in the non-aversive arm. But, at 24-h after training, Wistar rats remained less time in the aversive closed arm in comparison with the non-aversive one, while Proechimys rodents spent the same amount of time in both enclosed arms. In the object recognition test, both species were evaluated at 24-h after the acquisition session and similar findings than those of the PM-DAT (24-h) were obtained, suggesting that long-term memory duration did not persist for 24-h in the Amazon rodent. Field excitatory post-synaptic potentials recordings revealed that LTP decays rapidly over time reaching basal levels at 90 min after theta-burst stimulation in Proechimys, contrasting to the stable LTP found in the Wistar rats which was observed throughout 3-h recording period. These findings suggest a link between the LTP decay and the lack of 24-h long-lasting memory process in Proechimys. Nevertheless, why early-phase LTP in Proechimys decays very rapidly remains to be elucidated. en
dc.description.sponsorship CEPID/FAPESP
dc.description.sponsorship FAPESP/CNPq/MCT-Instituto Nacional de Neurociencia Translacional
dc.format.extent -
dc.language.iso eng
dc.publisher Frontiers Media Sa
dc.relation.ispartof Frontiers In Behavioral Neuroscience
dc.rights Acesso aberto
dc.subject memory en
dc.subject long-term potentiation en
dc.subject learning en
dc.subject anxiety en
dc.subject hippocampus en
dc.subject plus-maze discriminative avoidance task en
dc.title Long-term Potentiation Decay and Poor Long-lasting Memory Process in the Wild Rodents Proechimys from Brazil's Amazon Rainforest en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurocirurgia, Disciplina Neurociencia, Sao Paulo, Brazil
dc.description.affiliation Univ Nacl Autonoma Honduras, Fac Ciencias Med, Dept Ciencias Morfol, Tegucigalpa, Honduras
dc.description.affiliation Univ Strasbourg, INSERM U1114, Neuropsychol Cognit, Physiopathol Schizophrenie, Strasbourg, France
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Farmacol, Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Psicobiol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Neurol & Neurocirurgia, Disciplina Neurociencia, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Farmacol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Psicobiol, Sao Paulo, Brazil
dc.description.sponsorshipID CEPID/FAPESP: 2013/08028-1
dc.description.sponsorshipID FAPESP/CNPq/MCT: 573604/2008-8
dc.identifier.file WOS000423068200001.pdf
dc.identifier.doi 10.3389/fnbeh.2018.00002
dc.description.source Web of Science
dc.identifier.wos WOS:000423068200001
dc.coverage Lausanne
dc.citation.volume 12



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