Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo

Morpho/Proteomic Comparative between High Grade Pleomorphic Sarcoma and Metastasis Diagnosed in an Old Captive Common Hippo

Author Silva, Adriana R. Autor UNIFESP Google Scholar
de Lacerda, Jose T. J. G. Autor UNIFESP Google Scholar
Faria, Bernadete Autor UNIFESP Google Scholar
da Cunha, Isabela W. Google Scholar
de Andrade, Vitor P. Google Scholar
Assuncao, Nilson A. Autor UNIFESP Google Scholar
Abstract Old age is a risk factor for cancer development in humans and animals, and studies have shown that tumors in animals are acceptable models for studying human cancers, considering the similarities between their factors. This work was conducted in a 53-year-old captive female common hippo (Hippopotamus amphibious) with a left leg tumor and metastatic mass. Histopathological and immunohistochemical analyses were carried out with a final diagnosis of a high grade pleomorphic sarcoma. A proteomic study using mass spectrometry was added in order to identify further aspects of the primary tumor and metastasis which could improve our understanding, and each tissue showed a proteomic profile indicative of its pathologic state with significant differences between healthy tissue, primary and metastatic tumors. Low levels of beta-actin in primary tumors were identified, and this may be associated with a possible consequence of cytoskeleton dynamic modification. In metastatic tissue, these dynamics may be affected by the presence of HSP chaperone 60.
Keywords Hippopotamus amphibious
high grade pleomorphic sarcoma
cytoskeleton
beta-actin
mass spectrometry
xmlui.dri2xhtml.METS-1.0.item-coverage Sao Paulo
Language English
Sponsor FAPESP: 2012/02514-9
Date 2018
Published in Journal Of The Brazilian Chemical Society. Sao Paulo, v. 29, n. 2, p. 363-370, 2018.
ISSN 0103-5053 (Sherpa/Romeo, impact factor)
Publisher Soc Brasileira Quimica
Extent 363-370
Origin http://dx.doi.org/10.21577/0103-5053.20170149
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000416209700017
SciELO ID S0103-50532018000200363 (statistics in SciELO)
URI https://repositorio.unifesp.br/handle/11600/54245

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