Multiple trial inhibitory avoidance acquisition and retrieval are resistant to chronic stress

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dc.contributor.author Raya, J. [UNIFESP]
dc.contributor.author Girardi, C. E. N. [UNIFESP]
dc.contributor.author Esumi, L. A. [UNIFESP]
dc.contributor.author Ferreira, L. B. T. [UNIFESP]
dc.contributor.author Hipolide, D. C. [UNIFESP]
dc.date.accessioned 2020-07-08T13:09:49Z
dc.date.available 2020-07-08T13:09:49Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.1016/j.beproc.2017.12.008
dc.identifier.citation Behavioural Processes. Amsterdam, v. 147, p. 28-32, 2018.
dc.identifier.issn 0376-6357
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/54221
dc.description.abstract Chronic mild stress (CMS) is a widely accepted animal model relevant to depression that among other consequences, is chiefly known to induce anhedonia, often assessed as decreased preference for sucrose solution. CMS is also known to affect cognition, particularly memory tasks. In this study we have employed the multiple trial inhibitory avoidance memory task (MTIA) to assess CMS effects on memory acquisition and retrieval. MTIA consists of repeated exposures to the unconditioned stimulus until a learning criterion is reached. Wistar rats underwent CMS for 5 weeks, and sucrose consumption was assessed once a week. At the end of CMS, animals were evaluated in the MTIA task. Overall decreased sucrose solution preference was highly variable. Further analyses showed that a subset of animals expressed resilience while another subset was sensitive to stress. CMS did not affect the number of acquisition sessions before reaching criterion or retrieval latency of MTIA task in neither sensitive nor resilient groups. Although tasks that assess learning ability in animal models relevant to depression indicate cognitive deficits, the ability to learn the association between compartment crossing and the aversive electric foot shock, which is strongly dependent on emotional aspects, was intact. en
dc.description.sponsorship Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.format.extent 28-32
dc.language.iso eng
dc.publisher Elsevier Science Bv
dc.relation.ispartof Behavioural Processes
dc.rights Acesso restrito
dc.subject Chronic stress en
dc.subject Sucrose preference en
dc.subject Anhedonia en
dc.subject Inhibitory avoidance en
dc.subject Stress sensitivity en
dc.title Multiple trial inhibitory avoidance acquisition and retrieval are resistant to chronic stress en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
dc.description.affiliation Univ Ibirapuera, Programa Posgrad Psicossomat, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2012/00017-8]
dc.description.sponsorshipID CNPq: 473329/2011-5
dc.identifier.doi 10.1016/j.beproc.2017.12.008
dc.description.source Web of Science
dc.identifier.wos WOS:000423645400005
dc.coverage Amsterdam
dc.citation.volume 147



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