The hyperleptinemia state can downregulate cardiorespiratory fitness and energy expenditure in obese women

The hyperleptinemia state can downregulate cardiorespiratory fitness and energy expenditure in obese women

Author Sanches, Ricardo Badan Autor UNIFESP Google Scholar
Schoenardie Poli, Vanessa Fadanelli Autor UNIFESP Google Scholar
Novo Fidalgo, Joao Pedro Autor UNIFESP Google Scholar
Andrade-Silva, Stephan Garcia Autor UNIFESP Google Scholar
Cerrone, Leticia Andrade Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Damaso, Ana Raimunda Autor UNIFESP Google Scholar
dos Santos, Ronaldo Thomatieli Autor UNIFESP Google Scholar
Caranti, Danielle Arisa Autor UNIFESP Google Scholar
Abstract Introduction: In general, in obese people a state of hyperleptinemia may impair both energy balance and the inflammatory process. However, it has not been fully investigated whether there is a relationship between hyperleptinemia and cardiorespiratory fitness (CRF) and resting energy expenditure (REE), in obese women. Methods: 83 obese women were enrolled in this cross-sectional study. Anthropometric measures, body composition, REE, CRF and serum concentration of leptin were measured. Pearson's correlation coefficient was performed to examine the relationship between circulating leptin level and other clinical variables. Multiple regression analysis was applied to determine predictors of REE and CRF. Effects were considered significant at p <= 0.05. Results: The most important finding in the present study is that the hyperleptinemia state was inversely correlated with CRF (r = -0.382, p = 0.001) and REE (r = -0.447, p < 0.001). Moreover, a positive correlation with fat mass was confirmed (r = 0.419, p < 0.001). In addition, hyperleptinemia was an independent negative predictor of REE (r(2) = -2.649, p = 0.010) and CRF (r(2) = -2.335, p = 0.023). Conclusion: Together our results may suggest a vicious cycle between the state of hyperleptinemia and a decrease in energy expenditure and cardiorespiratory fitness in obese women, which can impair whole body energy homeostasis. This information is important to contribute to clinical practices.
Keywords Aerobic evaluation
Cytokines
Energy balance
Fat mass
Obesity
Physiology
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor CAPES-Reuni
FAPESP
CNPQ
Grant number FAPESP: 011/51723-7
CNPQ: 471108/2011-1
Date 2018
Published in Physiology & Behavior. Oxford, v. 184, p. 34-38, 2018.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 34-38
Origin http://dx.doi.org/10.1016/j.physbeh.2017.10.029
Access rights Closed access
Type Article
Web of Science ID WOS:000423637200005
URI https://repositorio.unifesp.br/handle/11600/54218

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