Assessing cardiovascular risk in ATM heterozygotes

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dc.contributor.author de Almeida Kotchetkoff, Elaine Cristina [UNIFESP]
dc.contributor.author Suano de Souza, Fabiola Isabel [UNIFESP]
dc.contributor.author Affonso Fonseca, Fernando Luiz [UNIFESP]
dc.contributor.author Hix, Sonia
dc.contributor.author Ajzen, Sergio Aron [UNIFESP]
dc.contributor.author Shigueoka, David Carlos [UNIFESP]
dc.contributor.author Costa Carvalho, Beatriz Tavares [UNIFESP]
dc.contributor.author Saccardo Sarni, Roseli Oselka [UNIFESP]
dc.date.accessioned 2020-07-08T13:09:42Z
dc.date.available 2020-07-08T13:09:42Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.1590/1806-9282.64.02.148
dc.identifier.citation Revista Da Associacao Medica Brasileira. Sao Paulo, v. 64, n. 2, p. 148-153, 2018.
dc.identifier.issn 0104-4230
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/54153
dc.description.abstract Objective: To evaluate the carotid intima-media complex (CIMC) thickness and lipid metabolism biomarkers associated with cardiovascular risk (CR) in parents of patients with ataxia-telangiectasia and verify an association with gender. Method: A cross-sectional and controlled study with 29 ATM heterozygotes and 14 healthy controls. Biochemical tests and CIMC thickness measurement were performed. Results: The mean CIMC measurement in heterozygous ATM was 0.72 +/- 0.1 mm (minimum: 0.5 mm and maximum: 1.0 mm). Noticed high percentage of amounts above 75 percentile compared to the population referential (16 [76.2%]), without any significant statistical differences between the female and the male gender (11/15 [73.3%] vs. 5/6 [83.3%] en
dc.description.abstract p=0.550). The comparison between heterozygous and controls, stratified by gender, showed that in heterozygous ATMs, women had higher concentrations of HDL-c compared to men, as well as higher values of hs-CRP in relation to the control women. In heterozygous ATMs, stratified by gender, the correlation between HDL-c and hs-CRP was inversely proportional and stronger among women, with a tendency to statistical significance. Conclusion: Heterozygous ATMs did not differ from controls in relation to the biomarkers studied related to CR. However, most of them presented increased CIMC, independent predictor of death, risk for myocardial infarction and stroke, compared to the referential for the same age group. This finding suggests CR in the heterozygous ATM and shows to the need to monitor CIMC thickness and nutritional orientations. en
dc.format.extent 148-153
dc.language.iso eng
dc.publisher Assoc Medica Brasileira
dc.relation.ispartof Revista Da Associacao Medica Brasileira
dc.rights Acesso aberto
dc.subject Ataxia Telangiectasia en
dc.subject Atherosclerosis en
dc.subject Carotid Intima-Media Thickness en
dc.subject Insulin Resistance en
dc.subject Heterozygote en
dc.title Assessing cardiovascular risk in ATM heterozygotes en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo EPM Unifesp, Escola Paulista Med, Pediat Dept, Sao Paulo, SP, Brazil
dc.description.affiliation Fac Med ABC FMABC, Santo Andre, SP, Brazil
dc.description.affiliation Unifesp, Diadema, SP, Brazil
dc.description.affiliation FMABC, Dept Morphol & Physiol, Santo Andre, SP, Brazil
dc.description.affiliation EPM Unifesp, Dept Diagnost Imaging, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo EPM Unifesp, Escola Paulista Med, Pediat Dept, Sao Paulo, SP, Brazil
dc.description.affiliationUnifesp Unifesp, Diadema, SP, Brazil
dc.description.affiliationUnifesp EPM Unifesp, Dept Diagnost Imaging, Sao Paulo, SP, Brazil
dc.identifier.file S0104-42302018000200148.pdf
dc.identifier.scielo S0104-42302018000200148
dc.identifier.doi 10.1590/1806-9282.64.02.148
dc.description.source Web of Science
dc.identifier.wos WOS:000429487700011
dc.coverage Sao Paulo
dc.citation.volume 64
dc.citation.issue 2



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