Assessing risk of bias in randomized controlled trials of methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)

Assessing risk of bias in randomized controlled trials of methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)

Author Rodrigues-Tartari, Raissa Autor UNIFESP Google Scholar
Swardfager, Walter Google Scholar
Salum, Giovanni A. Google Scholar
Rohde, Luis A. Google Scholar
Cogo-Moreira, Hugo Autor UNIFESP Google Scholar
Abstract To test how reliable the tool recommend by Cochrane Collaboration for assessing risk of bias systematic reviews of randomized clinical trials is in the context of methylphenidate for children and adolescents with attention deficit hyperactivity disorder. Confirmatory factor analysis was used to evaluate a unidimensional model for the 7 indicators, applied to 184 Randomized Clinical Trial (RCTs) within a 2015 Cochrane systematic review titled Methylphenidate for children and adolescents with attention deficit hyperactivity disorder. A unidimensional model resulted in excellent adequacy indices, but only 2 indicators had very high factor loadings and low measurement errors. In terms of content, the 7 indicators showed poor reliability (=0.642)

however, the set of indicators was precise in evaluating studies with a high amount of bias risk. The Cochrane model of risk of bias as it is, exhibited good fit indices but the majority of the items were not reliable to adequately capture risk of bias in the context of clinical trials of methylphenidate for ADHD.
Keywords ADHD
confirmatory factor analysis
meta-analysis
methylphenidate
risk of bias
xmlui.dri2xhtml.METS-1.0.item-coverage Hoboken
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
Grant number FAPESP: 2016/08208-8
Date 2018
Published in International Journal Of Methods In Psychiatric Research. Hoboken, v. 27, n. 1, p. -, 2018.
ISSN 1049-8931 (Sherpa/Romeo, impact factor)
Publisher Wiley
Extent -
Origin http://doi.org/10.1002/mpr.1586
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000426505900009
URI https://repositorio.unifesp.br/handle/11600/54047

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