Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection

Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection

Autor Oliveira, Gabriel Melo De Google Scholar
Masuda, Masako Oya Google Scholar
Rocha, Nazaré N Google Scholar
Schor, Nestor Autor UNIFESP Google Scholar
Hooper, Cléber S Google Scholar
Araújo-jorge, Tânia C De Google Scholar
Henriques-pons, Andréa Google Scholar
Instituição Instituto Oswaldo Cruz-Fiocruz Laboratório de Biologia Celular
Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas Filho
Universidade Federal Fluminense Instituto Biomédico Departamento de Fisiologia e Farmacologia
Universidade Federal de São Paulo (UNIFESP)
Centro de Criação de Animais de Laboratório Departamento de Controle de Qualidade Animal
Resumo Trypanosoma cruzi infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the physiological network of disturbances imposed by the infection has not been addressed thoroughly. Regarding myocarditis induced by the infection, we observed in our previous work that Fas-L-/- mice (gld/gld) have very mild inflammatory infiltration when compared to BALB/c mice. However, all mice from both lineages die in the early acute phase. Therefore, in this work we studied the physiological connection relating arterial pressure, renal function/damage and cardiac insufficiency as causes of death. Our results show that a broader set of dysfunctions that could be classified as a cardio/anaemic/renal syndrome is more likely responsible for cardiac failure and death in both lineages. However, gld/gld mice had very early glomerular deposition of IgM and a more intense renal inflammatory response with reduced renal filtration, which is probably responsible for the premature death in the absence of significant myocarditis in gld/gld.
Palavra-chave Trypanosoma cruzi
Fas-L
myocarditis
acute kidney injury
Idioma Inglês
Data de publicação 2009-12-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 104, n. 8, p. 1063-1071, 2009.
ISSN 0074-0276 (Sherpa/Romeo, fator de impacto)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 1063-1071
Fonte http://dx.doi.org/10.1590/S0074-02762009000800002
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000274413300002
SciELO S0074-02762009000800002 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/5401

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