Grape skin extract mitigates tissue degeneration, genotoxicity, and oxidative status in multiple organs of rats exposed to cadmium

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dc.contributor.author Boiago Gollucke, Andrea P. [UNIFESP]
dc.contributor.author Claudio, Samuel R. [UNIFESP]
dc.contributor.author Yamamura, Hirochi [UNIFESP]
dc.contributor.author Morais, Damila R.
dc.contributor.author Bataglion, Giovana A.
dc.contributor.author Eberlin, Marcos N.
dc.contributor.author Aguiar, Odair, Jr. [UNIFESP]
dc.contributor.author Ribeiro, Daniel A. [UNIFESP]
dc.date.accessioned 2020-07-02T18:52:14Z
dc.date.available 2020-07-02T18:52:14Z
dc.date.issued 2018
dc.identifier http://dx.doi.org/10.1097/CEJ.0000000000000273
dc.identifier.citation European Journal Of Cancer Prevention. Philadelphia, v. 27, n. 1, p. 70-81, 2018.
dc.identifier.issn 0959-8278
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/53972
dc.description.abstract The aim of this study was to investigate whether grape skin extract can mitigate the noxious activities induced by cadmium exposure in multiple organs of rats. For this purpose, histopathological analysis for the liver, genotoxicity, and oxidative status in the blood and liver were investigated in this setting. A total of 20 Wistar rats weighing 250g, on average, and 8 weeks of age were distributed into four groups (n=5) as follows: control group (nontreated group) en
dc.description.abstract cadmium group (Cd) en
dc.description.abstract and grape skin extract groups (Cd+GS) at 175 or 350mg/l. Histopathological analysis in liver showed that animals treated with grape skin extract showed improved tissue degeneration induced by cadmium intoxication. Genetic damage was reduced in blood and hepatocytes as indicated by comet and micronucleus assays in animals treated with grape skin extract. Copper-zinc superoxide dismutase and cytochrome c gene expression increased in groups treated with grape skin extract in liver cells. Grape skin extract also reduced the 8-hydroxy-2-deoxyguanosine levels in liver cells compared with the cadmium group. Taken together, our results indicate that grape skin extract can mitigate tissue degeneration, genotoxicity, and oxidative stress induced by cadmium exposure in multiple organs of Wistar rats. en
dc.description.sponsorship CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
dc.description.sponsorship CAPES (Coordenacao de Aperfeicoamento de Pessoal de NIvel Superior)
dc.format.extent 70-81
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof European Journal Of Cancer Prevention
dc.rights Acesso restrito
dc.subject cadmium en
dc.subject genotoxicity en
dc.subject grape skin extract en
dc.subject oxidative stress en
dc.subject rat en
dc.title Grape skin extract mitigates tissue degeneration, genotoxicity, and oxidative status in multiple organs of rats exposed to cadmium en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Biosci, Sao Paulo, Brazil
dc.description.affiliation Univ Estadual Campinas, UNICAMP, Inst Chem, ThoMSon Mass Spectrometry Lab, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Biosci, Sao Paulo, Brazil
dc.identifier.doi 10.1097/CEJ.0000000000000273
dc.description.source Web of Science
dc.identifier.wos WOS:000417289000011
dc.coverage Philadelphia
dc.citation.volume 27
dc.citation.issue 1



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