Genotoxicity and cytotoxicity induced by eluates from orthodontic glass ionomer cements in vitro

Genotoxicity and cytotoxicity induced by eluates from orthodontic glass ionomer cements in vitro

Author Angelieri, Fernanda Google Scholar
da Silva, Yuri Slusarenko Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Abstract The aim of this study was to investigate genotoxicity and cytotoxicity of some orthodontic glass ionomer cements commercially available by means of the single cell gel (comet) assay. For this purpose, five commercial orthodontic glass ionomer cements (Vidrion C (R), Meron (R), Optiband (R), Multicure (R) and Ultra Band Lok (R)) were tested in murine fibroblasts in vitro. For this purpose, eluates from each cement were prepared according manufactures instructions at 0, 2, 4, 8, 18, 32 and 64 days of immersion in artificial saliva at 37 degrees C. All orthodontic glass ionomer cements failed to induce cytotoxicity to murine fibroblasts for all periods evaluated in this study. However, Vidrion C (R) was able to induce genotoxicity after 64 days of exposure to eluates. Meron (R) also demonstrated genotoxicity as depicted by increasing DNA damage on 2nd day. Multicure (R) demonstrated genotoxicity on 32nd day and Ultra band Lok on 18th, 32nd days of exposure. Taken together, our results demonstrated that orthodontic cements derived from resin-modified glass ionomer composite (Multicure (R)) and compomer (Ultra Band Lok (R)) cause genetic damage in mammalian cells in vitro. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license.
Keywords Genotoxicity
Glass ionomer cements
Murine fibroblasts
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor CNPq (National Council for Scientific and Technological Development) fellowship
Date 2018
Published in Saudi Dental Journal. Amsterdam, v. 30, n. 1, p. 38-42, 2018.
ISSN 1013-9052 (Sherpa/Romeo, impact factor)
Publisher Elsevier Science Bv
Extent 38-42
Access rights Closed access
Type Article
Web of Science ID WOS:000419045300007

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