Leukocyte telomere length variation in different stages of schizophrenia

Leukocyte telomere length variation in different stages of schizophrenia

Author Maurya, Pawan Kumar Autor UNIFESP Google Scholar
Rizzo, Lucas Bortolotto Autor UNIFESP Google Scholar
Xavier, Gabriela Autor UNIFESP Google Scholar
Tempaku, Priscila Farias Autor UNIFESP Google Scholar
Ota, Vanessa Kiyomi Autor UNIFESP Google Scholar
Santoro, Marcos L. Autor UNIFESP Google Scholar
Spindola, Leticia M. Autor UNIFESP Google Scholar
Moretti, Patricia S. Autor UNIFESP Google Scholar
Mazzotti, Diego R. Google Scholar
Gadelha, Ary Autor UNIFESP Google Scholar
Gouvea, Eduardo S. Google Scholar
Noto, Cristiano Autor UNIFESP Google Scholar
Maes, Michael Google Scholar
Cordeiro, Quirino Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Belangero, Sintia Iole Autor UNIFESP Google Scholar
Abstract Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effect of genetic and environmental factors in patients with first-episode psychosis (FEP) and schizophrenia (SCZ). Eighty-one participants with antipsychotic-naive FEP, 173 with SCZ and 438 HC were enrolled in this study. Psychiatric diagnosis was assessed using the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I). The Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS) and Calgary Depression Scale for Schizophrenia (CDSS) were used to measure symptoms severity. Telomere length (TL) was determined using a multiplex qPCR assay. After adjustment for age, years of education, and smoking status, we found that patients with SCZ had longer TL (relative ratio (RR) = 1.08) than the HC group (RR = 1.00, Wald chi(2) = 12.48, p = 0.002). Further, non-remitted SCZ patients presented longer TL (RR = 1.00) compared to remitted SCZ (RR = 0.88, Wald chi(2) = 7.20, p = 0.007). TL in patients also correlated to psychopathology assessment in terms of total (p = 0.003) and positive PANSS scores (p = 0.001). No correlation with negative PANSS, YMRS, and CDSS or effects of medication was found on TL. Although the exact pathways underlying longer TL in SCZ patients remain unclear, these findings raise more questions than answers and suggest that TL may be of immense value on SCZ progression. Further studies are required to investigate the association of TL in FEP and SCZ.
Keywords Telomere length
First-episode psychosis
Schizophrenia
Progression
xmlui.dri2xhtml.METS-1.0.item-coverage Oxford
Language English
Sponsor Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP) - Brazil
Coordination of Improvement of Higher Education Personnel (CAPES)
National Counsel of Technological and Scientific Development (CNPq), Brazil
Grant number FAPESP: 2014/07280-1
FAPESP: 2010/08968-6
CNPq: 457217/2014-6
Date 2018
Published in Journal Of Psychiatric Research. Oxford, v. 96, p. 218-223, 2018.
ISSN 0022-3956 (Sherpa/Romeo, impact factor)
Publisher Pergamon-Elsevier Science Ltd
Extent 218-223
Origin http://dx.doi.org/10.1016/j.jpsychires.2017.10.016
Access rights Closed access
Type Article
Web of Science ID WOS:000419412800029
URI https://repositorio.unifesp.br/handle/11600/53945

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