Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient

Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient

Author Camargo, Rosalinda Yasato Google Scholar
Kanamura, Cristina Takami Google Scholar
Friguglietti, Celso Ubirajara Google Scholar
Nogueira, Celia Regina Google Scholar
Iorcansky, Sonia Google Scholar
Tincani, Alfio Jose Google Scholar
Bezerra, Ana Karina Google Scholar
Brust, Ester Google Scholar
Koyama, Fernanda Christtanini Google Scholar
Camargo, Anamaria Aranha Google Scholar
Rego, Fernanda Orpinelli R. Google Scholar
Favoretto Galante, Pedro Alexandre Google Scholar
Medeiros-Neto, Geraldo Google Scholar
Sanchez Rubio, Ileana Gabriela Google Scholar
Abstract Ectopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small follicles

one sample exhibited a normal thyroid pattern while four showed colloid goiter. All ectopic thyroids expressed the specific thyroid genes and T4 at similar locations to those observed in normal thyroid. No somatic mutations associated with ectopic thyroid were found. This is the first immature thyroid fetal tissue observed in an ectopic thyroid due to the arrest of structural differentiation early in the colloid stage of development that proved able to synthesize thyroid hormone but not to respond to TSH. Despite the ability of all ectopic thyroids to synthetize specific thyroid proteins and T4, at some point in life, it may be insufficient to support body growth leading to hypothyroidism, as observed in some of the patients.
xmlui.dri2xhtml.METS-1.0.item-coverage London
Language English
Sponsor FAPESP Grant [2009/53840-0]
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Sao Paulo, Brazil [2010/12005-9, 2014/24549-4]
Instituto da Tiroide
Grant number FAPESP [2009/53840-0]
FAPESP[2010/12005-9, 2014/24549-4]
Date 2018
Published in International Journal Of Endocrinology. London, v. , p. -, 2018.
ISSN 1687-8337 (Sherpa/Romeo, impact factor)
Publisher Hindawi Ltd
Extent -
Origin http://dx.doi.org/10.1155/2018/4682876
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000425414300001
URI https://repositorio.unifesp.br/handle/11600/53866

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