Angiotensin II or epinephrine hemodynamic and metabolic responses in the liver of L-NAME induced hypertension and spontaneous hypertensive rats

Angiotensin II or epinephrine hemodynamic and metabolic responses in the liver of L-NAME induced hypertension and spontaneous hypertensive rats

Author Kimura, Debora Conte Autor UNIFESP Google Scholar
Nagaoka, Marcia Regina Autor UNIFESP Google Scholar
Borges, Durval Rosa Autor UNIFESP Google Scholar
Kouyoumdjian, Maria Autor UNIFESP Google Scholar
Abstract AIM To study hepatic vasoconstriction and glucose release induced by angiotensin (Ang) II or Epi in rats with pharmacological hypertension and spontaneously hypertensive rat (SHR). METHODS Isolated liver perfusion was performed following portal vein and vena cava cannulation

Ang. or epinephrine (Epi) was injected in bolus and portal pressure monitored

glucose release was measured in perfusate aliquots. RESULTS The portal hypertensive response (PHR) and the glucose release induced by Ang. of L-NAME were similar to normal rats (WIS). On the other hand, the PHR induced by Epi in L-NAME was higher whereas the glucose release was lower compared to WIS. Despite the similar glycogen content, glucose release induced by Ang. was lower in SHR compared to Wistar-Kyoto rats although both PHR and glucose release induced by Epi in were similar. CONCLUSION Ang. and Epi responses are altered in different ways in these hypertension models. Our results suggest that inhibition of NO production seems to be involved in the hepatic effects induced by Epi but not by Ang.

the diminished glucose release induced by Ang. in SHR is not related to glycogen content.
Keywords Epinephrine
Liver perfusion
Spontaneously hypertensive rat
Glucose
Angiotensin II
L-NAME
xmlui.dri2xhtml.METS-1.0.item-coverage Pleasanton
Language English
Sponsor Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
Grant number FAPESP: 2011/13974-8|CAPES
Date 2017
Published in World Journal Of Hepatology. Pleasanton, v. 9, n. 17, p. 781-790, 2017.
ISSN 1948-5182 (Sherpa/Romeo, impact factor)
Publisher Baishideng Publishing Group Inc
Extent 781-790
Origin http://dx.doi.org/10.4254/wjh.v9.i17.781
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000404572500003
URI https://repositorio.unifesp.br/handle/11600/53650

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