The interfaces between vitamin D, sleep and pain

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dc.contributor.author de Oliveira, Daniela Leite [UNIFESP]
dc.contributor.author Hirotsu, Camila [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Andersen, Monica Levy [UNIFESP]
dc.date.accessioned 2020-06-26T16:30:31Z
dc.date.available 2020-06-26T16:30:31Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.1530/JOE-16-0514 ]
dc.identifier.citation Journal Of Endocrinology. Bristol, v. 234, n. 1, p. R23-R36, 2017.
dc.identifier.issn 0022-0795
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/53590
dc.description.abstract The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested its action on different biological mechanisms, such as nociceptive sensitivity and sleep-wake cycle modulation. Sleep is an important biological process regulated by different regions of the central nervous system, mainly the hypothalamus, in combination with several neurotransmitters. Pain, which can be classified as nociceptive, neuropathic and psychological, is regulated by both the central and peripheral nervous systems. In the peripheral nervous system, the immune system participates in the inflammatory process that contributes to hyperalgesia. Sleep deprivation is an important condition related to hyperalgesia, and recently it has also been associated with vitamin D. Poor sleep efficiency and sleep disorders have been shown to have an important role in hyperalgesia, and be associated with different vitamin D values. Vitamin D has been inversely correlated with painful manifestations, such as fibromyalgia and rheumatic diseases. Studies have demonstrated a possible action of vitamin D in the regulatory mechanisms of both sleep and pain. The supplementation of vitamin D associated with good sleep hygiene may have a therapeutic role, not only in sleep disorders but also in the prevention and treatment of chronic pain conditions. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorship Sao Paulo Research Foundation ( FAPESP)
dc.format.extent R23-R36
dc.language.iso eng
dc.publisher Bioscientifica Ltd
dc.relation.ispartof Journal Of Endocrinology
dc.rights ACESSO ABERTO
dc.subject sleep en
dc.subject vitamin D en
dc.subject pain en
dc.subject hyperalgesia en
dc.title The interfaces between vitamin D, sleep and pain en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, Brazil
dc.description.sponsorshipID AFIP
dc.description.sponsorshipID FAPESP: 2014/15259-2
dc.description.sponsorshipID FAPESP: 2016/02205-7
dc.identifier.file WOS000404980300004.pdf
dc.identifier.doi 10.1530/JOE-16-0514
dc.description.source Web of Science
dc.identifier.wos WOS:000404980300004
dc.coverage Bristol
dc.citation.volume 234 ]
dc.citation.issue 1 ]



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