The interfaces between vitamin D, sleep and pain

The interfaces between vitamin D, sleep and pain

Author de Oliveira, Daniela Leite Autor UNIFESP Google Scholar
Hirotsu, Camila Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Abstract The role of vitamin D in osteomineral metabolism is well known. Several studies have suggested its action on different biological mechanisms, such as nociceptive sensitivity and sleep-wake cycle modulation. Sleep is an important biological process regulated by different regions of the central nervous system, mainly the hypothalamus, in combination with several neurotransmitters. Pain, which can be classified as nociceptive, neuropathic and psychological, is regulated by both the central and peripheral nervous systems. In the peripheral nervous system, the immune system participates in the inflammatory process that contributes to hyperalgesia. Sleep deprivation is an important condition related to hyperalgesia, and recently it has also been associated with vitamin D. Poor sleep efficiency and sleep disorders have been shown to have an important role in hyperalgesia, and be associated with different vitamin D values. Vitamin D has been inversely correlated with painful manifestations, such as fibromyalgia and rheumatic diseases. Studies have demonstrated a possible action of vitamin D in the regulatory mechanisms of both sleep and pain. The supplementation of vitamin D associated with good sleep hygiene may have a therapeutic role, not only in sleep disorders but also in the prevention and treatment of chronic pain conditions.
Keywords sleep
vitamin D
pain
hyperalgesia
xmlui.dri2xhtml.METS-1.0.item-coverage Bristol
Language English
Sponsor Associacao Fundo de Incentivo a Pesquisa (AFIP)
Sao Paulo Research Foundation ( FAPESP)
Grant number AFIP
FAPESP: 2014/15259-2
FAPESP: 2016/02205-7
Date 2017
Published in Journal Of Endocrinology. Bristol, v. 234, n. 1, p. R23-R36, 2017.
ISSN 0022-0795 (Sherpa/Romeo, impact factor)
Publisher Bioscientifica Ltd
Extent R23-R36
Origin http://dx.doi.org/10.1530/JOE-16-0514
Access rights ACESSO ABERTO
Type Article
Web of Science ID WOS:000404980300004
URI https://repositorio.unifesp.br/handle/11600/53590

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