Effects of Carbohydrate and Glutamine Supplementation on Oral Mucosa Immunity after Strenuous Exercise at High Altitude: A Double-Blind Randomized Trial

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dc.contributor.author Caris, Aline Venticinque [UNIFESP]
dc.contributor.author Da Silva, Edgar Tavares [UNIFESP]
dc.contributor.author Dos Santos, Samile Amorim [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Thomatieli Dos Santos, Ronaldo Vagner [UNIFESP]
dc.date.accessioned 2020-06-26T16:30:28Z
dc.date.available 2020-06-26T16:30:28Z
dc.date.issued 2017
dc.identifier http://dx.doi.org/10.3390/nu9070692 ]
dc.identifier.citation Nutrients. Basel, v. 9, n. 7, p. -, 2017.
dc.identifier.issn 2072-6643
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/53554
dc.description.abstract This study analyzed the effects of carbohydrate and glutamine supplementation on salivary immunity after exercise at a simulated altitude of 4500 m. Fifteen volunteers performed exercise of 70% of VO2peak until exhaustion and were divided into three groups: hypoxia placebo, hypoxia 8% maltodextrin (200 mL/20 min), and hypoxia after six days glutamine (20 g/day) and 8% maltodextrin (200 mL/20 min). All procedures were randomized and double-blind. Saliva was collected at rest (basal), before exercise (pre-exercise), immediately after exercise (post-exercise), and two hours after exercise. Analysis of Variance (ANOVA) for repeated measures and Tukey post hoc test were performed. Statistical significance was set at p < 0.05. SaO(2)% reduced when comparing baseline vs. pre-exercise, post-exercise, and after recovery for all three groups. There was also a reduction of SaO(2)% in pre-exercise vs. post-exercise for the hypoxia group and an increase was observed in pre-exercise vs. recovery for both supplementation groups, and between post-exercise and for the three groups studied. There was an increase of salivary flow in post-exercise vs. recovery in Hypoxia + Carbohydrate group. Immunoglobulin A (IgA) decreased from baseline vs. post-exercise for Hypoxia + Glutamine group. Interleukin 10 (IL-10) increased from post-exercise vs. after recovery in Hypoxia + Carbohydrate group. Reduction of tumor necrosis factor alpha (TNF-alpha) was observed from baseline vs. post-exercise and after recovery for the Hypoxia + Carbohydrate group en
dc.description.abstract a lower concentration was observed in pre-exercise vs. post-exercise and recovery. TNF-alpha had a reduction from baseline vs. post-exercise for both supplementation groups, and a lower secretion between baseline vs. recovery, and pre-exercise vs. post-exercise for Hypoxia + Carbohydrate group. Five hours of hypoxia and exercise did not change IgA. Carbohydrates, with greater efficiency than glutamine, induced anti-inflammatory responses. en
dc.format.extent -
dc.language.iso eng
dc.publisher Mdpi Ag
dc.relation.ispartof Nutrients
dc.rights ACESSO ABERTO
dc.subject supplementation en
dc.subject carbohydrate en
dc.subject hypoxia en
dc.subject physical exercise en
dc.subject glutamine en
dc.subject high altitude en
dc.subject innate immune response en
dc.subject oral mucosal immunity en
dc.title Effects of Carbohydrate and Glutamine Supplementation on Oral Mucosa Immunity after Strenuous Exercise at High Altitude: A Double-Blind Randomized Trial en
dc.type Artigo
dc.description.affiliation Univ Fed Sao Paulo, Dept Psychobiol, BR-04032020 Sao Paulo, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Biosci, BR-11015020 Santos, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Psychobiol, BR-04032020 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Biosci, BR-11015020 Santos, Brazil
dc.identifier.file WOS000406679700049.pdf
dc.identifier.doi 10.3390/nu9070692
dc.description.source Web of Science
dc.identifier.wos WOS:000406679700049
dc.coverage Basel
dc.citation.volume 9 ]
dc.citation.issue 7 ]



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